Transplantation Immunology

Methods and Protocols

  • Philip Hornick
  • Marlene Rose

Part of the Methods In Molecular Biology™ book series (MIMB, volume 333)

Table of contents

  1. Front Matter
    Pages i-x
  2. Christopher J. Callaghan, J. Andrew Bradley
    Pages 1-27
  3. Peter J. Friend, Charles J. Imber
    Pages 29-46
  4. Jonathan R. T. Lakey, Mohammadreza Mirbolooki, A. M. James Shapiro
    Pages 47-103
  5. Allan R. Glanville
    Pages 105-130
  6. Philip Hornick, Marlene Rose
    Pages 131-144
  7. Philip Hornick
    Pages 145-156
  8. Stephen Sheldon, Kay Poulton
    Pages 157-174
  9. Charlotte Lawson
    Pages 175-199
  10. Louise Collins
    Pages 201-225
  11. Luis Graca, Herman Waldmann
    Pages 247-267
  12. Maria P. Hernandez-Fuentes, Alan Salama
    Pages 269-290
  13. Emma McGregor, Ayesha De Souza
    Pages 291-304
  14. Leanne E. Felkin, Anne B. Taegtmeyer, Paul J. R. Barton
    Pages 305-330
  15. Mark Hicks, Alfred Hing, Ling Gao, Jonathon Ryan, Peter S. MacDonald
    Pages 331-373
  16. Peter Mark Anthony Hopkins
    Pages 375-399
  17. Bezhad Soleimani, Victor C. Shi
    Pages 401-423
  18. Back Matter
    Pages 425-429

About this book


Technical innovations in the laboratory over the past ten years have greatly improved our understanding of the immunological mechanisms of transplanted organ rejection. In Transplantation Immunology: Methods and Protocols, leading experts in solid organ transplantation review the current status of the field and describe cutting-edge techniques for detecting the immune response to the allografted organ. The authors present the latest techniques for HLA typing, detecting HLA antibodies, and monitoring T-cell response, and examine more specialized methods of utilizing proteomics, laser dissection microscopy, and real-time polymerase chain reaction. The areas of tolerance induction and reprogramming of the immune system are also covered, along with a discussion of up-to-date methods of organ preservation, of today's optimal immunosuppressive drug regimens, as well as the difficulty of mimicking chronic rejection in experimental models. Introductory chapters provide a theoretical update on current practices in renal, liver, islet, and lung transplantation and on the pathways of antigen presentation and chronic rejection.
State of the art and highly practical, Transplantation Immunology: Methods and Protocols illuminates for clinicians and scientists-both newcomers and experts-the new world of detecting and monitoring patients' immunological responses to solid organ transplantation.


Antigen antigen presentation gene transfer genes immune response immune system immunology liver transplantation microscopy organ organ transplantation transplantation

Editors and affiliations

  • Philip Hornick
    • 1
  • Marlene Rose
    • 2
  1. 1.National Heart and Lung InstituteLondonUK
  2. 2.National Heart and Lung InstituteHarefieldUK

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2006
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-544-6
  • Online ISBN 978-1-59745-049-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site