Histone Deacetylases

Transcriptional Regulation and Other Cellular Functions

  • Eric┬áVerdin

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Class I Histone Deacetylases

    1. Front Matter
      Pages 1-1
    2. Dominique Meunier, Christian Seiser
      Pages 3-22
    3. Alejandro Vaquero, Michael Scher, Danny Reinberg
      Pages 23-60
    4. Edward Seto
      Pages 61-86
    5. David Waltregny, Vincent Castronovo
      Pages 87-104
  3. Class II Histone Deacetylases

    1. Front Matter
      Pages 105-105
    2. Timothy A. McKinsey, Eric N. Olson
      Pages 107-128
    3. Herbert G. Kasler, Eric Verdin
      Pages 129-163
    4. J. Andrew McKee, Tso-Pang Yao
      Pages 165-180
  4. Class III Histone Deacetylases

    1. Front Matter
      Pages 181-181
    2. Margie T. Borra, John M. Denu
      Pages 219-235
    3. Bjoern Schwer, Brian J. North, Nidhi Ahuja, Brett Marshall, Eric Verdin
      Pages 237-268
  5. Histone Deacetylase Inhibitors

    1. Front Matter
      Pages 269-269
    2. Akihiro Ito, Norikazu Nishino, Minoru Yoshida
      Pages 271-297
    3. Paul Kwon, Meier Hsu, Dalia Cohen, Peter Atadja
      Pages 315-332
  6. Back Matter
    Pages 333-340

About this book

Introduction

The recent discoveries that established histone acetylation as a key regulatory mechanism for gene expression triggered a wave of interest in histone posttranslational modifications and led to the development of novel anticancer agents now in clinical trials. In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of leading investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small-molecule inhibitors-and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice.
Authoritative and state-of-the-art, Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions constitutes a first landmark of what has been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come.

Keywords

biochemistry biology cell enzymes proteins vertebrates

Editors and affiliations

  • Eric┬áVerdin
    • 1
  1. 1.Gladstone Institute of Virology and ImmunologyUniversity of CaliforniaSan Francisco

Bibliographic information

  • DOI https://doi.org/10.1385/1597450243
  • Copyright Information Humana Press Inc. 2006
  • Publisher Name Humana Press
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-58829-499-9
  • Online ISBN 978-1-59745-024-9
  • About this book