The Orexin/Hypocretin System

Physiology and Pathophysiology

  • Seiji Nishino
  • Takeshi Sakurai

Part of the Contemporary Clinical Neuroscience book series (CCNE)

Table of contents

  1. Front Matter
    Pages i-xii
  2. History

    1. Front Matter
      Pages 1-1
    2. Michihiro Mieda, Takeshi Sakurai
      Pages 3-10
  3. Overview of the Orexin/Hypocretin Neuronal System

    1. Front Matter
      Pages 11-11
    2. Takeshi Sakurai
      Pages 13-20
    3. Jacob N. Marcus, Joel K. Elmquist
      Pages 21-43
    4. Anthony N. van den Pol, Claudio Acuna-Goycolea
      Pages 45-60
    5. Akihiro Yamanaka
      Pages 61-70
  4. Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids

    1. Front Matter
      Pages 71-71
    2. René Bernard, Ralph Lydic, Helen A. Baghdoyan
      Pages 83-96
  5. Physiology

    1. Front Matter
      Pages 97-97
    2. Takeshi Sakurai
      Pages 99-106
    3. Tetsuro Shirasaka, Masamitsu Nakazato
      Pages 107-117
    4. Yoichi Ueta, Hiroaki Fujihara
      Pages 131-140
  6. Physiology

    1. Front Matter
      Pages 141-141
    2. Luis de Lecea, J. Gregor Sutcliffe
      Pages 143-153
    3. Yasushi Yoshida, Seiji Nishino
      Pages 155-173
    4. Rodrigo A. España, Thomas E. Scammell
      Pages 189-207
    5. Jerome M. Siegel
      Pages 209-217
  7. Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency

    1. Front Matter
      Pages 219-219
    2. Scott Fromherz, Emmanuel Mignot
      Pages 221-231
    3. Seiji Nishino
      Pages 233-253
    4. Michihiro Mieda, Masashi Yanagisawa
      Pages 255-266
  8. Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency

    1. Front Matter
      Pages 267-267
    2. Patrice Bourgin, Jamie M. Zeitzer, Emmanuel Mignot
      Pages 269-286
    3. Takashi Kanbayashi, Junko Arii, Hideaki Kondo, Tetsuo Shimizu, Seiji Nishino
      Pages 287-316
    4. Ronald M. Salomon
      Pages 317-327
    5. Gert Jan Lammers, Sebastiaan Overeem, Hanno Pijl
      Pages 329-339
    6. Shahrad Taheri, Jose Paterno, Ling Lin, Emmauel Mignot
      Pages 341-346
  9. Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency

    1. Front Matter
      Pages 347-347
    2. Stephen J. Perry, David A. Schwarz, Richard A. Maki
      Pages 349-357
    3. Michihiro Mieda, Jon T. Willie, Takeshi Sakurai
      Pages 359-366
  10. Back Matter
    Pages 389-397

About this book


Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations.
Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.


Nervous System biological fluid clinical application neuroendocrinology neurons pathophysiology physiology tissue

Editors and affiliations

  • Seiji Nishino
    • 1
  • Takeshi Sakurai
    • 2
  1. 1.Center for NarcolepsyStanford University School of MedicineStanford
  2. 2.Department of Pharmacology Institute of Basic Medical SciencesUniversity of TsukubaIbarakiJapan

Bibliographic information