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The Adrenergic Receptors

In the 21st Century

  • Dianne M. Perez

Part of the The Receptors book series (REC)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Historical Perspectives

    1. Front Matter
      Pages 1-1
    2. David B. Bylund
      Pages 3-21
  3. Structure-Function

    1. Front Matter
      Pages 23-23
    2. Angela M. Finch, Valerie Sarramegna, Robert M. Graham
      Pages 25-85
    3. Kenneth P. Minneman
      Pages 87-106
    4. Michael T. Piascik, Mary Lolis García-Cazarin, Steven R. Post
      Pages 107-128
    5. Martin C. Michel, Paul A. Insel
      Pages 129-147
  4. Imaging Adrenergic Receptors and Their Function

  5. Genetically Altered Mouse Models

    1. Front Matter
      Pages 205-205
    2. Paul C. Simpson
      Pages 207-240
    3. Christopher M. Tan, Lee E. Limbird
      Pages 241-265
    4. Yang Xiang, Brian Kobilka
      Pages 267-291
    5. Cinzia Perrino, Liza Barki-Harrington, Howard A. Rockman
      Pages 293-320
    6. Andrea D. Eckhart, Walter J. Koch
      Pages 321-335
  6. Pharmacogenomics

    1. Front Matter
      Pages 337-337
    2. Boyd Rorabaugh, June Yun, Dianne M. Perez
      Pages 365-391
  7. Summary and Future Endeavors

    1. Front Matter
      Pages 393-393
    2. Dianne M. Perez
      Pages 395-396
  8. Back Matter
    Pages 397-404

About this book

Introduction

The adrenergic receptors control many critical functions of the heart, kidney, brain, and all organs under autonomic control. Today significant opportunities exist for molecular and genetic analysis of their function and signaling pathways. In The Adrenergic Receptors: In the 21st Century, senior scientists who have developed novel molecular approaches describe the state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Many of the methods described can be applied to characterize any receptor of interest. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on both clinical outcomes and potential gene therapy applications. Additional chapters address modern techniques for assessing adrenergic function, such as fluorescent labeling and microarrays, and offer an insightful historical survey of the extraordinary progress made in our understanding of these receptors in the twentieth century.
Comprehensive and authoritative, The Adrenergic Receptors: In the 21st Century provides researchers-through its side-by-side comparison of all the adrenergic receptors (a1, a2, and b) and their subtypes-with an excellent survey of the field, including the rationale for how best to design better drugs for control of the heart, blood pressure, and related pathophysiological systems.

Keywords

blood blood pressure gene gene therapy genomics imaging medicine microarray mouse outcome receptor signaling regulation research signal transduction therapy

Editors and affiliations

  • Dianne M. Perez
    • 1
  1. 1.Department of Molecular Cardiology, The Lerner Research InstituteThe Cleveland Clinic FoundationCleveland

Bibliographic information

  • DOI https://doi.org/10.1385/1592599311
  • Copyright Information Humana Press Inc. 2006
  • Publisher Name Humana Press
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-58829-423-4
  • Online ISBN 978-1-59259-931-8
  • Series Print ISSN 1048-6909
  • Series Online ISSN 2524-6488
  • Buy this book on publisher's site