Bone Metastasis

Experimental and Clinical Therapeutics

  • Gurmit Singh
  • Shafaat A. Rabbani

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Fundamental Concepts

    1. Front Matter
      Pages 1-1
    2. Sadmeet Singh, Gurmit Singh
      Pages 3-12
    3. Richard Kremer, Shafaat A. Rabbani
      Pages 29-57
    4. Alison L. Allan, Alan B. Tuck, Vivien H. C. Bramwell, Theodore A. Vandenberg, Eric W. Winquist, Ann F. Chambers
      Pages 107-123
    5. Ryan R. Simon, Martin K. Butcher, Stephen G. Shaughnessy
      Pages 125-132
    6. Sujata Persad, Gurmit Singh
      Pages 133-146
    7. Leonard J. Deftos, D. W. Burton, Randolph H. Hastings
      Pages 147-175
    8. Shaker A. Mousa
      Pages 177-187
  3. Therapeutic Strategies

    1. Front Matter
      Pages 189-189
    2. Pierre P. Major, Richard J. Cook
      Pages 191-199
    3. Graham C. Parry, Fernando Doñate, Marian L. Plunkett, David E. Shaw, Steven Pirie-Shepherd, Andrew P. Mazar
      Pages 201-227
    4. Laurie A. McDuffee, Nigel Colterjohn, Gurmit Singh
      Pages 229-241
    5. Shane Burch, Albert J. M. Yee
      Pages 243-253
    6. Ellen K. Wasan, Martin Gleave, Karen Fang, Kim Chi, Gwyn Bebb, Lincoln Edwards et al.
      Pages 255-292
    7. Eric Seidlitz, Zeina Saikali, Gurmit Singh
      Pages 293-303
    8. Arif Hussain, Fred Saad
      Pages 305-321
    9. Edward Chow, Jackson Wu, Elizabeth Toni Barnes
      Pages 323-336
  4. Back Matter
    Pages 337-344

About this book


Bone metastasis occurs in 60 to 85% of all breast, prostate, and lung cancer patients and is responsible for increasing morbidity. In Bone Metastasis: Experimental and Clinical Therapeutics, leading bone metastasis experts from around the world explain the molecular underpinnings of the process, review current treatment approaches, and outline future therapeutic strategies. On the basic science side, the authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. On the therapeutic side, the authors discuss various strategies that appear to have promise and are currently deployed in treatment or at the experimental stage. They show how the treatment of bone metastases may need to be individualized through a combination of surgical, radiation, and/or pharmacological maneuvers. Their analysis of various pharmacogenomic parameters and tissue environmental factors sets the stage for progress beyond the current standards of using radiation and/or bisphosphonates for palliation.
State-of-the-art and innovative, Bone Metastasis: Experimental and Clinical Therapeutics elucidates for all those involved-whether in research or clinical treatment of bone-seeking cancers-the biological processes and therapeutic advances that are already generating significant improvement in the cancer clinic.


angiogenesis bisphosphonates cancer cell hormones metastasis oncology pain prostate cancer tissue tumor tumor growth tumor progression

Editors and affiliations

  • Gurmit Singh
    • 1
  • Shafaat A. Rabbani
    • 2
  1. 1.Department of Pathology and Molecular Medicine/Juravinski Cancer CentreMcMaster UniversityHamiltonCanada
  2. 2.Calcium Research LaboratoryMcGill University Health CentreMontrealCanada

Bibliographic information

  • DOI
  • Copyright Information Humana Press Inc. 2005
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-403-6
  • Online ISBN 978-1-59259-892-2
  • Buy this book on publisher's site