Table of contents

  1. Front Matter
    Pages i-x
  2. Manish A. Shah, Gary K. Schwartz
    Pages 27-60
  3. John M. Burke, David A. Scheinberg, Joseph G. Jurcic
    Pages 107-131
  4. Owen A. O’Connor
    Pages 133-174
  5. Shanu Modi, Monica N. Fornier, Andrew D. Seidman
    Pages 175-195
  6. Don S. Dizon, Carol Aghajanian, X. Jun Yan, David R. Spriggs
    Pages 197-207
  7. Luba Benimetskaya, Sridhar Mani, C. A. Stein
    Pages 209-230
  8. Back Matter
    Pages 277-284

About this book

Introduction

Early clinical trials of the new molecular-based anticancer agents have shown that many are marginal in controlling cancer, but prove to be potent modulators and potentiators of chemotherapy-induced apoptosis when used in combination with classic cytotoxic drugs or radiation. In Combination Cancer Therapy: Modulators and Potentiators, expert physician-scientists and clinicians with first-hand experience in the clinical development of targeted therapies review those combinations that hold the most promise for the future of medical oncology, detailing their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory benchtop to the patient's bedside as a new generation of cancer therapeutics.
Cutting-edge and forward-looking, Combination Cancer Therapy: Modulators and Potentiators offers everyone in the fields of cancer drug development and therapy a powerful new understanding of the optimal sequencing and scheduling of new combination drug therapies necessary to maximize the effects for cancer patients today.

Keywords

Chemotherapie apoptosis carcinoma cell leukemia ovarian cancer

Editors and affiliations

  • Gary K. Schwartz
    • 1
  1. 1.Division of Solid Tumor Oncology, Department of MedicineMemorial Sloan-Kettering Cancer CenterNew York

Bibliographic information

  • DOI https://doi.org/10.1385/1592598641
  • Copyright Information Humana Press Inc. 2005
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-200-1
  • Online ISBN 978-1-59259-864-9
  • About this book