Death Receptors in Cancer Therapy

  • Wafik S. El-Deiry

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xi
  2. E. Robert McDonald III, Wafik S. El-Deiry
    Pages 1-41
  3. David J. McConkey
    Pages 43-64
  4. Sarah G. Hymowitz, Abraham M. de Vos
    Pages 65-81
  5. Nien-Jung Chen, Wen-Chen Yeh
    Pages 93-109
  6. Mi-Hyang Kim, Dai-Wu Seol
    Pages 133-148
  7. Sug Hyung Lee, Nam Jin Yoo, Jung Young Lee
    Pages 149-162
  8. Udo Kontny, Heinrich Kovar
    Pages 163-173
  9. Peter Hersey, Si Yi Zhang, Xu Dong Zhang
    Pages 175-187
  10. Rishu Takimoto
    Pages 201-206
  11. Tanya Tekautz, Tal Teitz, Jill M. Lahti, Vincent J. Kidd
    Pages 207-229
  12. Mahaveer Swaroop Bhojani, Brian D. Ross, Alnawaz Rehemtulla
    Pages 263-279
  13. Subrata Ray, John G. Hissong, Marcela Oancea, Alex Almasan
    Pages 281-296
  14. Rüdiger Göke, Youhai H. Chen
    Pages 297-303
  15. James S. Norris, David H. Holman, Marc L. Hyer, Alicja Bielawska, Ahmed El-Zawahry, Charles Chalfant et al.
    Pages 323-338
  16. Lidong Zhang, Bingliang Fang
    Pages 339-354
  17. Simone Fulda, Klaus-Michael Debatin
    Pages 355-366
  18. Back Matter
    Pages 367-374

About this book


Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.
Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.


TNF apoptosis carcinoma cell cell death gene therapy interferon melanoma prostate cancer tumor

Editors and affiliations

  • Wafik S. El-Deiry
    • 1
    • 2
    • 3
  1. 1.Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphia
  2. 2.Department of GeneticsUniversity of Pennsylvania School of MedicinePhiladelphia
  3. 3.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphia

Bibliographic information

  • DOI
  • Copyright Information Humana Press Inc. 2005
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-172-1
  • Online ISBN 978-1-59259-851-9
  • Buy this book on publisher's site