Brain Tumors

  • FrancisĀ Ali-Osman

Part of the Contemporary Cancer Research book series (CCR)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Epidemiology, Biology, Genetics, and Pathology

    1. Front Matter
      Pages 1-1
    2. Randa El-Zein, Melissa Bondy, Margaret Wrensch
      Pages 3-18
    3. Catherine L. Nutt, Anat O. Stemmer-Rachamimov, J. Gregory Cairncross, David N. Louis
      Pages 33-53
    4. Martin Begemann, Vinagolu K. Rajasekhar, Gregory N. Fuller, Eric C. Holland
      Pages 55-89
    5. Minsoo Kang, Takamitsu Fujimaki, Seiji Yano, Isaiah J. Fidler
      Pages 91-106
    6. John R. Hill, Shoichiro Ohta, Mark A. Israel
      Pages 125-154
  3. Mechanisms and Pathways

    1. Front Matter
      Pages 155-155
    2. Helga E. de Vries, Lisette Montagne, Christine D. Dijkstra, Paul van der Valk
      Pages 157-174
    3. Lois A. Lampson
      Pages 175-205
    4. Hiroko Ohgaki, Paul Kleihues
      Pages 207-221
    5. Henry S. Friedman, M. Eileen Dolan, Francis Ali-Osman
      Pages 223-235
    6. Juan Fueyo, Candelaria Gomez-Manzano, Timothy J. McDonnell
      Pages 249-264
  4. Therapeutics

    1. Front Matter
      Pages 265-265
    2. Charles A. Conrad, W. K. Alfred Yung
      Pages 267-277
    3. Nalin Gupta, John R. Fike, Penny K. Sneed, Philip J. Tofilon, Dennis F. Deen
      Pages 279-305
    4. Fadi Hanbali, Raymond Sawaya
      Pages 307-322
    5. Amy B. Heimberger, David A. Reardon, Darell D. Bigner, John H. Sampson
      Pages 323-342
    6. Maciej S. Lesniak, James Frazier, Henry Brem
      Pages 343-358
    7. Francis Ali-Osman, Henry S. Friedman, Gamil R. Antoun, David Reardon, Darell D. Bigner, John K. Buolamwini
      Pages 359-381
  5. Back Matter
    Pages 383-393

About this book


In recent years, elucidation of many exciting details of the complex cellular and molecular processes involved in the initiation, progression, and clinical and biological behavior of brain tumors has greatly deepened our understanding of these cancers, and is now leading to new paradigms in their diagnosis and treatment. In Brain Tumors, Francis Ali-Osman, DSc, has assembled a panel of leading experts to summarize and illuminate the full range of recent research advances in their rapidly evolving field, with particular emphasis on those that are providing novel insights into the disease. The chapters critically assess current knowledge and the challenges of the future in relevant areas of brain research, including basic mechanisms of neuro-oncogenesis, molecular neurobiology, genetics, epidemiology, pathology, immunology, and therapy. New knowledge is critically presented on molecular profiling, molecular pathology and classification, in vitro and in vivo brain tumor models, brain metastasis, and progenitor cell biology. They also discuss in depth the cellular and genetic pathways involved in brain oncogenesis, malignant progression, and therapeutic response, highlighting oncogenes and tumor suppressor genes, DNA damage and repair, invasion and migration, cell cycle, growth factors, signaling, apoptosis, and developmental biology. The discussion of brain tumor therapy focuses on advances in pharmacological thinking, therapeutic modalities, novel therapeutic targets, rational drug design, gene and viral therapies, drug delivery and the blood-brain barrier, immunotherapy, and brain imaging.
Authoritative and comprehensive, Brain Tumors provides an essential state-of-the-art guide to productive work across the entire range of basic and clinical research in neuro-oncology today. For the both active researcher and the trainee, the book will provide an appreciation of new neuro-oncology concepts and facilitate incorporating them into their own ongoing research.


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Editors and affiliations

  • FrancisĀ Ali-Osman
    • 1
    • 2
  1. 1.Department of SurgeryDuke University Medical CenterDurham
  2. 2.Comprehensive Cancer CenterDuke University Medical CenterDurham

Bibliographic information