Cartilage and Osteoarthritis

Volume 2: Structure and In Vivo Analysis

  • Frédéric De Ceuninck
  • Massimo Sabatini
  • Philippe Pastoureau

Part of the Methods in Molecular Medicine book series (MIMM, volume 101)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Anna-Marja Säämänen, Eero Vuorio
    Pages 1-23
  3. Jean-Charles Rousseau, Linda J. Sandell, Pierre D. Delmas, Patrick Garnero
    Pages 25-37
  4. James Melrose, Susan Smith, Peter Ghosh
    Pages 39-63
  5. Philippe Pastoureau, Agnès Chomel
    Pages 79-91
  6. Martin Judex, Elena Neumann, Steffan Gay, Ulf Müller-Ladner
    Pages 93-105
  7. Albert C. Chen, Stephen M. Klisch, Won C. Bae, Michele M. Temple, Kevin B. McGowan, Kenneth R. Gratz et al.
    Pages 157-190
  8. Jürgen Schiller, Daniel Huster, Beate Fuchs, Lama Naji, Jörn Kaufmann, Klaus Arnold
    Pages 267-285
  9. Jürgen Schiller, Lama Naji, Robert Trampel, Wilfred Ngwa, Robert Knauss, Klaus Arnold
    Pages 287-302
  10. Daniel Huster, Jürgen Schiller, Klaus Arnold
    Pages 303-318
  11. Sandra Martelli, Stefano Zaffagnini
    Pages 319-338
  12. Back Matter
    Pages 339-343

About this book


Osteoarthritis (OA), the most common form of arthritis, imposes a significant burden of suffering on a growing population of the elderly. Even today, its poorly understood pathophysiology limits the discovery of molecular targets for pharmacological intervention and there are few effective medical treatments beyond pain control and surgery. In Cartilage and Osteoarthritis a distinguished panel of researchers, physicians, and opinion leaders in this challenging field describe their updated classical, but still evolving, techniques, as well as many emerging methods that promise to add significantly to our understanding of cartilage metabolism in health and disease. Volume 2: Structure and In Vivo Analysis, offers cutting-edge procedures for studies-at the tissue level-of turnover, structure, and functioning in normal and diseased cartilage by invasive and noninvasive means. The protocols follow the successful Methods in Molecular Medicine™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. A companion volume, Volume 1: Cellular and Molecular Tools, describes proven molecular and cellular techniques for the in vitro study of normal and osteoarthritic cartilage through biochemical, biomolecular, immunological, and physical approaches, with emphasis on the genetic manipulation of cells.
Comprehensive and up-to-date, the two volumes of Cartilage and Osteoarthritis provide researchers and bench scientists alike with an indispensable collection of readily reproducible protocols for new experiments-from the cellular to the animal level-designed to more clearly describe the pathophysiology of cartilage, as well as to discover novel molecular targets for pharmacological intervention.


Arthritis bone cartilage computed tomography computed tomography (CT) imaging joint metabolism osteoarthritis pathophysiology physiology protein research sonography tissue

Editors and affiliations

  • Frédéric De Ceuninck
    • 1
  • Massimo Sabatini
    • 1
  • Philippe Pastoureau
    • 1
  1. 1.Division de RhumatologieInstitut de Recherches ServierSuresnesFrance

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2004
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-505-7
  • Online ISBN 978-1-59259-821-2
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site