Cartilage and Osteoarthritis

Volume 1: Cellular and Molecular Tools

  • Massimo Sabatini
  • Philippe Pastoureau
  • Frédéric De Ceuninck

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 100)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Sylvie Thirion, Francis Berenbaum
    Pages 1-14
  3. Frédéric De Ceuninck, Christophe Lesur, Philippe Pastoureau, Audrey Caliez, Massimo Sabatini
    Pages 15-22
  4. Luis A. Solchaga, Jean F. Welter, Donald P. Lennon, Arnold I. Caplan
    Pages 53-67
  5. Audrey McAlinden, Jochen Haag, Brigitte Bau, Pia M. Gebhard, Thomas Aigner
    Pages 79-100
  6. Frédéric Mallein-Gerin, Jérôme Gouttenoire
    Pages 101-104
  7. Frédéric Mallein-Gerin, Jérôme Gouttenoire
    Pages 105-108
  8. Thomas Aigner, Joachim Saas, Alexander Zien, Ralf Zimmer, Pia M. Gebhard, Thomas Knorr
    Pages 109-127
  9. Jean F. Welter, Luis A. Solchaga, Matthew C. Stewart
    Pages 129-145
  10. Jean-Noel Gouze, Martin J. Stoddart, Elvire Gouze, Glyn D. Palmer, Steven C. Ghivizzani, Alan J. Grodzinsky et al.
    Pages 147-163
  11. Anne-Marie Freyria, Michel Becchi
    Pages 165-182
  12. Gust Verbruggen, Jun Wang, Lai Wang, Dirk Elewaut, Eric M. Veys
    Pages 183-208
  13. Frédéric De Ceuninck, Audrey Caliez
    Pages 209-217
  14. John S. Mort, Peter J. Roughley
    Pages 237-249
  15. R. Clark Billinghurst, Fackson Mwale, Anthony Hollander, Mirela Ionescu, A. Robin Poole
    Pages 251-273
  16. Darryl D. D’Lima, Klaus Kuhn, Martin K. Lotz
    Pages 275-289
  17. David A. Lee, Martin M. Knight
    Pages 307-324
  18. Kelvin W. Li, Travis J. Klein, Kanika Chawla, Gayle E. Nugent, Won C. Bae, Robert L. Sah
    Pages 325-351
  19. Back Matter
    Pages 353-358

About this book


Osteoarthritis, the most common form of arthritis, imposes a significant burden of suffering on a growing population of the elderly. Even today, its poorly understood pathophysiology limits the discovery of molecular targets for pharmacological intervention and there are few effective medical treatments beyond pain control and surgery. In Cartilage and Osteoarthritis a distinguished panel of researchers, physicians, and opinion leaders in this challenging field describe their updated classical, but still evolving, techniques, as well as many emerging methods that promise to add significantly to our understanding of cartilage metabolism in health and disease. Volume 1: Cellular and Molecular Tools describes proven molecular and cellular techniques for the in vitro study of normal and osteoarthritic cartilage through biochemical, biomolecular, immunological, and physical approaches, with emphasis on the genetic manipulation of cells. The protocols follow the successful Methods in Molecular Medicine™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. A companion volume, Volume 2: Structure and In Vivo Analysis, offers cutting-edge procedures for studies-at the tissue level-of turnover, structure, and functioning in normal and diseased cartilage by invasive and noninvasive means.
Comprehensive and up-to-date, the two volumes of Cartilage and Osteoarthritis provide researchers and bench scientists alike with an indispensable collection of readily reproducible protocols for new experiments-from the cellular to the animal level-designed to more clearly describe the pathophysiology of cartilage, as well as to discover novel molecular targets for pharmacological intervention.

Editors and affiliations

  • Massimo Sabatini
    • 1
  • Philippe Pastoureau
    • 1
  • Frédéric De Ceuninck
    • 1
  1. 1.Division de RhumatologieInstitut de Recherches ServierSuresnesFrance

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2004
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-247-6
  • Online ISBN 978-1-59259-810-6
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site