Genomics, Proteomics, and Clinical Bacteriology

Methods and Reviews

  • Neil Woodford
  • Alan P. Johnson

Part of the Methods in Molecular Biology™ book series (MIMB, volume 266)

Table of contents

  1. Front Matter
    Pages i-x
  2. Principles of Bacterial Genomics

    1. Front Matter
      Pages 1-1
    2. Mark J. Pallen
      Pages 3-15
    3. Neil Woodford
      Pages 17-28
    4. Makoto Kuroda, Keiichi Hiramatsu
      Pages 29-45
    5. Matthew B. Avison
      Pages 47-69
    6. Peter M. Bennett
      Pages 71-113
    7. Stuart J. Cordwell
      Pages 115-135
  3. Application of Genomics to Diagnostic Bacteriology

    1. Front Matter
      Pages 137-137
    2. B. Cherie Millar, John E. Moore
      Pages 139-166
    3. Peter Marsh, Donald L. N. Cardy
      Pages 167-189
    4. Nicholas A. Saunders
      Pages 191-211
    5. Carola Van Ijperen, Nicholas A. Saunders
      Pages 213-227
  4. Interrogating Bacterial Genomes

    1. Front Matter
      Pages 229-229
    2. David J. Payne, Michael N. Gwynn, David J. Holmes, Marty Rosenberg
      Pages 231-259
    3. Dawn Field, Jennifer Hughes, E. Richard Moxon
      Pages 261-287
    4. Dario E. Lehoux, François Sanschagrin, Irena Kukavica-Ibrulj, Eric Potvin, Roger C. Levesque
      Pages 289-304
    5. Andrew J. Lawson
      Pages 305-322
    6. Brian G. Spratt
      Pages 323-352
    7. Robert J. Owen
      Pages 353-383
  5. Back Matter
    Pages 385-395

About this book


It is essential that all clinical bacteriologists become active participants in the current genomics and proteomics revolution if the significant achievements of genome sequencing and analysis are to produce real benefits for patient care. In Genomics, Proteomics, and Clinical Bacteriology, a panel of internationally renowned experts reviews how genomics has provided novel methods for bacterial investigation and advanced our knowledge of bacterial pathogenicity. The authors critically evaluate the applications of genomics to diagnostic bacteriology, highlighting both current and likely future uses, describing real-time PCR methods, and outlining the promise of microarrays in clinical bacteriology. Their discussion examines in detail genomic approaches to antibacterial discovery, the nature of pathogenicity, the discovery of new pathogens, the exploration of the concept of clonality in bacteria, and bacterial taxonomics. Introductory material explains for the uninitiated the relevance of genomics to the clinical laboratory, illustrating the art and science of working with public databases, digging for data, and exploiting bacterial proteomes.
Comprehensive and insightful, Genomics, Proteomics, and Clinical Bacteriology offers everyone working in medical bacteriology an accessible introduction to a rapidly evolving discipline, one that shows not only how knowledge of bacterial genome sequences affects diagnostic bacteriology today, but also how that knowledge may be used in the future to gain new insights into bacterial disease processes, identify critical targets for antiinfectives, and aid in designing novel antibiotics.

Editors and affiliations

  • Neil Woodford
    • 1
  • Alan P. Johnson
    • 1
  1. 1.Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology DivisionHealth Protection Agency-ColindaleLondonUK

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2004
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-218-6
  • Online ISBN 978-1-59259-763-5
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site