Cytotoxic Drug Resistance Mechanisms

  • Robert Brown
  • Uta Böger-Brown

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 28)

Table of contents

  1. Front Matter
    Pages i-xi
  2. D. Alan Anthoney, Stanley B. Kaye
    Pages 1-15
  3. Jane A. Plumb
    Pages 17-23
  4. Jane A. Plumb
    Pages 25-30
  5. Neil A. Jones, Caroline Dive
    Pages 31-38
  6. Vicki Save, Philip J. Coates, Peter A. Hall
    Pages 39-52
  7. Henk J. Broxterman
    Pages 53-61
  8. Susan E. Bates, Zhirong Zhan, Joanna Regis, Erick Gamelin
    Pages 63-81
  9. Linda A. Hogarth, Celia M. A. Rabello, Andrew G. Hall
    Pages 91-94
  10. Philippe Pourquier, Glenda Kohlhagen, Li-Ming Ueng, Yves Pommier
    Pages 95-110
  11. Howard L. McLeod, Lesley H. Milne, Stephen J. Johnston
    Pages 111-120
  12. Michael J. Tilby
    Pages 121-128
  13. Adrian J. Frank
    Pages 129-141
  14. Victoria J. Spanswick, Janet M. Hartley, Timothy H. Ward, John A. Hartley
    Pages 143-154
  15. Gillian L. Hirst
    Pages 155-165
  16. Amanda J. Watson, Geoffrey P. Margison
    Pages 167-178
  17. Jonas Bergh
    Pages 179-199
  18. Lloyd R. Kelland, Philip J. Beale
    Pages 201-208
  19. Back Matter
    Pages 235-238

About this book


In Cytotoxic Drug Resistance Mechanisms, leading clinical and laboratory scientists describe cutting-edge methods for examining the mechanisms of cellular resistance to anticancer cytotoxics in human tumors. The protocols contain detailed instructions and extensive troubleshooting tips that allow researchers effectively to study a wide variety of drug resistance mechanisms, including aspects of drug-induced cell death, drug uptake/efflux, drug metabolism, and DNA repair. Each method is designed to help identify the correlation between molecular and biochemical data and the clinical responses of the patient.
Cytotoxic Drug Resistance Mechanisms makes it possible to test established and laboratory-derived hypotheses with clinically derived tumor samples. State-of-the-art and readily reproducible, the methods presented here afford basic and clinical scientists a powerful complement of tools for investigating all the clinically relevant mechanisms used as markers of the biological response to anticancer chemotherapeutics today.

Editors and affiliations

  • Robert Brown
    • 1
  • Uta Böger-Brown
    • 2
  1. 1.University of GlasgowGlasgowUK
  2. 2.BioMedExKillearnUK

Bibliographic information

  • DOI
  • Copyright Information Humana Press 1999
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-603-1
  • Online ISBN 978-1-59259-687-4
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site