Suicide Gene Therapy

Methods and Reviews

  • Caroline J. Springer

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 90)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Caroline J. Springer
    Pages 29-45
  3. Kenneth Brooks Low, Martina Ittensohn, Xiang Luo, Li-Mou Zheng, Ivan King, John M. Pawelek et al.
    Pages 47-59
  4. Masato Yamamoto, David T. Curiel
    Pages 61-70
  5. Gunnel Halldén, Stephen H. Thorne, Jingping Yang, David H. Kirn
    Pages 71-90
  6. Andrew D. Miller
    Pages 107-137
  7. Richard Brokx, Jean Gariépy
    Pages 139-160
  8. Dan Niculescu-Duvaz, Ion Niculescu-Duvaz, Caroline J. Springer
    Pages 161-202
  9. E. Antonio Chiocca, David J. Waxman
    Pages 203-222
  10. Kimberly V. Curlee, William B. Parker, Eric J. Sorscher
    Pages 223-245
  11. Mary K. Danks, Philip M. Potter
    Pages 247-262
  12. Alexandre Evrard, Joseph Ciccolini, Pierre Cuq, Jean-Paul Cano
    Pages 263-278
  13. Silke Schepelmann, Robert Spooner, Frank Friedlos, Richard Marais
    Pages 279-301
  14. Jean-Emmanuel Kurtz, Margaret E. Black
    Pages 331-344
  15. Wolfgang Uckert, Brian Salmons, Christian Beltinger, Walter H. Günzburg, Thomas Kammertöns
    Pages 345-352
  16. Shigeki Kuriyama, Hirohisa Tsujinoue, Hitoshi Yoshiji
    Pages 353-369
  17. Gabi U. Dachs, Olga Greco, Gillian M. Tozer
    Pages 371-387
  18. Simon D. Scott, Brian Marples
    Pages 389-402
  19. William R. Wilson, Susan M. Pullen, Alison Hogg, Stephen M. Hobbs, Frederik B. Pruijn, Kevin O. Hicks
    Pages 403-431
  20. Long R. Jiao, Roman Havlik, Joanna Nicholls, Steen Lindkaer Jensen, Nagy A. Habib
    Pages 433-450
  21. Nicola L. Brown, Nicholas R. Lemoine
    Pages 451-457
  22. Nicola K. Green, David J. Kerr, Vivien Mautner, Peter A. Harris, Peter F. Searle
    Pages 459-477
  23. Marjolijn M. van der Eb, Bertie de Leeuw, Alex J. van der Eb, Rob C. Hoeben
    Pages 479-490
  24. R. Barbara Pedley, Surinder K. Sharma, Robert E. Hawkins, Kerry A. Chester
    Pages 491-514
  25. Beatrice Seddon, Lloyd R. Kelland, Paul Workman
    Pages 515-542
  26. Back Matter
    Pages 543-555

About this book


Suicide gene therapy has become a major element in anticancer gene therapy and holds great promise for the future. In Suicide Gene Therapy: Methods and Reviews, prominent researchers and clinicians comprehensively detail the theory and practice of this exciting and elegant therapeutic approach. In their multidisciplinary treatment, the authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, the immunological implications, and its clinical impact. They also describe and expound upon all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results.
Authoritative and up-to-date, Suicide Gene Therapy: Methods and Reviews not only summarizes our knowledge of suicide gene therapy today, but also provides the experimental means to advance its future development and therapeutic applications.

Editors and affiliations

  • Caroline J. Springer
    • 1
  1. 1.Cancer Research UK Centre for Cancer Therapeutics at the Institute of Cancer ResearchSuttonUK

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2004
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-971-1
  • Online ISBN 978-1-59259-429-0
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site