The Blood-Brain Barrier

Biology and Research Protocols

  • Sukriti Nag

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 89)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Tissue Techniques

  3. Blood-Brain Barrier Permeability Techniques

  4. Blood-Brain Barrier Transport Techniques

    1. Front Matter
      Pages 191-191
    2. Quentin R. Smith, David D. Allen
      Pages 209-218
    3. Hiroyuki Kusuhara, Tetsuya Terasaki, Yuichi Sugiyama
      Pages 219-231
    4. Darryl R. Peterson, Richard A. Hawkins
      Pages 233-247
    5. Haiqing Dai, William F. Elmquist
      Pages 249-264
    6. Michelle A. Puchowicz, Kui Xu, Joseph C. LaManna
      Pages 265-276
    7. Laurence Fenart, Roméo Cecchelli
      Pages 277-290
    8. Nathalie Strazielle, Jane Elizabeth Preston
      Pages 291-304
  5. In Vitro Techniques

    1. Front Matter
      Pages 305-305
    2. Andreas Reichel, David J. Begley, N. Joan Abbott
      Pages 307-324
    3. Katerina Dorovini-Zis, Rukmini Prameya, Hanh Huynh
      Pages 325-336
    4. Jacqueline Shukaliak-Quandt, Donald Wong, Katerina Dorovini-Zis
      Pages 337-348
    5. Pierre-Olivier Couraud, John Greenwood, FranÇoise Roux, Pete Adamson
      Pages 349-364
    6. David A. Antonetti, Ellen B. Wolpert
      Pages 365-374
  6. Molecular Techniques

    1. Front Matter
      Pages 383-383
    2. William M. Pardridge
      Pages 385-399
    3. Ruben J. Boado
      Pages 401-418
    4. Matteo Marroni, Kelly M. Kight, Mohammed Hossain, Luca Cucullo, Shailesh Y. Desai, Damir Janigro
      Pages 419-434
    5. Jamshid Tanha, Arumugam Muruganandam, Danica Stanimirovic
      Pages 435-449
    6. Reiner F. Haseloff, Eberhard Krause, Ingolf E. Blasig
      Pages 465-477
    7. Christian T. Matson, Lester R. Drewes
      Pages 479-487
  7. Genetically Altered Mice

    1. Front Matter
      Pages 503-503
    2. Annette Damert, Heike Kusserow
      Pages 513-528
    3. Richard Rozmahel
      Pages 529-544
  8. Back Matter
    Pages 545-549

About this book


Despite the fact that the breakdown of the blood-brain barrier occurs in many brain diseases and is an important factor in mortality, the molecular mechanisms involved in the breakdown are not completely understood. In The Blood-Brain Barrier: Biology and Research Protocols, leading researchers and clinician-scientists present state-of-the-art morphologic, permeability, transport, in vitro, and molecular techniques to study the workings of the blood-brain barrier in health and disease. Described in step-by-step detail, each proven method includes an explanation of the theoretical basis of the method, a discussion of its advantages and limitations, notes on avoiding pitfalls, and examples of results obtained using the technique. At the cutting edge are techniques to explore the genomics and proteomics of brain endothelium.
Comprehensive and state-of-the-art, The Blood-Brain Barrier: Biology and Research Protocols offers pharmacologists, physiologists, neuroscientists, neurosurgeons, and neurologists an array of powerful tools to isolate undiscovered molecules, deepen our understanding of their role in health and disease, and identify targets for future gene therapy and therapeutic intervention.

Editors and affiliations

  • Sukriti Nag
    • 1
    • 2
  1. 1.Division of NeuropathologyUniversity of TorontoTorontoCanada
  2. 2.Toronto Western Research Institute and Department of PathologyUniversity Health NetworkTorontoCanada

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-073-1
  • Online ISBN 978-1-59259-419-1
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site