Book Volume 32 2000

Alzheimer's Disease

Methods and Protocols

Editors:

ISBN: 978-0-89603-737-3 (Print) 978-1-59259-195-4 (Online)

Table of contents (27 protocols)

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  1. Front Matter

    Pages i-xiv

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    Pages 1-21

    Introduction to Alzheimer's Disease

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    Protocol

    Pages 23-43

    The Genetics of Alzheimer's Disease

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    Protocol

    Pages 45-61

    Advances in Methodology and Current Prospects for Primary Drug Therapies for Alzheimer's Disease

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    Protocol

    Pages 63-78

    Production and Functional Assays of Recombinant Secreted Amyloid Precursor Protein (APP) (sAPPα)

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    Protocol

    Pages 79-89

    Quantifying Aβ1–40 and Aβ1–42 Using Sandwich-ELISA

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    Protocol

    Pages 91-99

    Electrophoretic Separation and Immunoblotting of Aβ1–40 and Aβ1–42

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    Protocol

    Pages 101-112

    Aβ-Induced Proinflammatory Cytokine Release from Differentiated Human THP-1 Monocytes

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    Pages 113-138

    Effects of the β-Amyloid Peptide on Membrane Ion Permeability

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    Pages 139-148

    Analysis of β-Amyloid Peptide Degradation In Vitro

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    Pages 149-168

    Posttranslational Modifications of Amyloid Precursor Protein

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    Protocol

    Pages 169-190

    Posttranslational Modifications of the Amyloid Precursor Protein

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    Protocol

    Pages 191-202

    Using an Amyloid Precursor Protein (APP) Reporter to Characterize α-Secretase

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    Protocol

    Pages 203-215

    Inhibition of α-Secretase by Zinc Metalloproteinase Inhibitors

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    Protocol

    Pages 217-228

    Development of Neoepitope Antibodies Against the β-Secretase Cleavage Site in the Amyloid Precursor Protein

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    Protocol

    Pages 229-238

    β-Secretase

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    Protocol

    Pages 239-248

    Using β-Secretase Inhibitors to Distiguish the Generation of the Aβ Peptides Terminating at Val-40 and Ala-42

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    Protocol

    Pages 249-270

    Designing Animal Models of Alzheimer's Disease with Amyloid Precursor Protein (APP) Transgenes

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    Pages 271-282

    Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins

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    Protocol

    Pages 283-296

    Determining the Transmembrane Topology of the Presenilins

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    Protocol

    Pages 297-308

    Normal Proteolytic Processing of the Presenilins

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