Parkinson's Disease

Methods and Protocols

  • M. Maral Mouradian

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 62)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Genetics

    1. Front Matter
      Pages 1-1
    2. Abbas Parsian, Joel S. Perlmutter
      Pages 3-11
    3. Hiroto Matsumine, Nobutaka Hattori, Yoshikuni Mizuno
      Pages 13-29
  3. Molecular Pathogenetic Studies

    1. Front Matter
      Pages 31-31
    2. Michel Goedert, Ross Jakes, R. Anthony Crowther, Maria Grazia Spillantini
      Pages 33-59
    3. Poul Henning Jensen
      Pages 61-65
    4. Ilan Ziv, Anat Shirvan, Daniel Offen, Ari Barzilai, Eldad Melamed
      Pages 73-87
    5. Tinmarla F. Oo, Rober E. Burke
      Pages 89-99
    6. Serge Przedborski, Ted M. Dawson
      Pages 113-136
    7. Moussa B. H. Youdim, Noam Drigues, Silvia Mandel
      Pages 137-153
  4. Molecular Aspects of Basal Ganglia Function

    1. Front Matter
      Pages 155-155
    2. Hiroshi Ichinose, Tamae Ohye, Takahiro Suzuki, Hidehito Inagaki, Toshiharu Nagatsu
      Pages 157-166
    3. Gary W. Miller, Yan-Min Wang, Raul R. Gainetdinov, Marc G. Caron
      Pages 179-190
    4. Sang-Hyeon Lee, M. Maral Mouradian
      Pages 191-215
    5. Sang-Hyeon Lee, M. Maral Mouradian
      Pages 217-227
    6. Claas-Hinrich Lammers, Yoshinobu Hara, M. Maral Mouradian
      Pages 229-246
  5. Molecular Therapies

    1. Front Matter
      Pages 255-255
    2. Richard Grondin, Zhiming Zhang, Dennis D. Elsberry, Greg A. Gerhardt, Don M. Gash
      Pages 257-267
    3. Krys S. Bankiewicz, Phillip Pivirotto, Rosario Sanchez-Pernaute, Eugene O. Major
      Pages 269-278
    4. Jack L. Tseng, Patrick Aebischer
      Pages 279-288
    5. Richard J.E. Armstrong, Anne E. Rosser, Stephen B. Dunnett, Roger A. Barker
      Pages 289-307
  6. Back Matter
    Pages 309-317

About this book


The use of molecular technologies to study Parkinson's disease in the laboratory is beginning to have a major impact in clinical medicine. In Parkinson's Disease: Methods and Protocols, internationally recognized biomedical investigators describe in detail the major techniques employed in molecular and cellular studies of Parkinson's disease and basal ganglia function, adding along the way considerable background information about the rationale and utility of these methods, as well as about fundamental issues in Parkinson's disease. Widely varied methods are covered, including genetic analyses, molecular pathogenetic investigations of dopaminergic neuronal degeneration, biochemical studies of nigrostriatal neural circuitry, and molecular therapies, such as gene therapy and neural stem cells.

Comprehensive and timely, Parkinson's Disease: Methods and Protocols offers scientists and clinicians interested in Parkinson's and related neurodegenerative disorders the major cutting-edge methods-in a readily reproducible format-needed to effectively exploit the potential of cell and molecular biology for elucidating disease mechanisms and for speeding the emergence of novel and more effective therapeutics.

Editors and affiliations

  • M. Maral Mouradian
    • 1
  1. 1.National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesda

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2001
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-761-8
  • Online ISBN 978-1-59259-142-8
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site