Molecular Pathology of the Prions

  • Harry F. Baker

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 59)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Hans A. Kretzschmar, Tobias Tings, Axel Madlung, Armin Giese, Jochen Herms
    Pages 17-30
  3. David R. Brown, Ian M. Jones
    Pages 31-50
  4. David R. Brown
    Pages 51-70
  5. Martin H. Groschup, Frauke Junghans, Martin Eiden, Thorsten Kuczius
    Pages 71-83
  6. Stephen J. DeArmond
    Pages 85-110
  7. Glenn C. Telling
    Pages 111-127
  8. Markus Glatzel, Sebastian Brandner, Michael A. Klein, Adriano Aguzzi
    Pages 129-147
  9. David A. Harris, Roberto Chiesa, Antonio Migheli, Pedro Piccardo, Bernardino Ghetti
    Pages 149-161
  10. Samar Betmouni, V. Hugh Perry
    Pages 163-179
  11. J. Richard Greene
    Pages 181-197
  12. Thomas Wisniewski, Einar M. Sigurdsson, Pierre Aucouturier, Blas Frangione
    Pages 223-236
  13. Reed B. Wickner, Herman K. Edskes, Kimberly L. Taylor, Marie-Lise Maddelein, Hiromitsu Moriyama, B. Tibor Roberts
    Pages 237-267
  14. Back Matter
    Pages 269-279

About this book


It is now widely agreed that the prion protein plays a key role in the molecular pathogenesis of prion diseases-diseases that involve the misfolding of proteins-in both humans and animals. In Molecular Pathology of the Prions, noted prion researcher Harry Baker has asked internationally recognized investigators to review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. Other topics addressed include the neuronal death that occurs in prion disease, the different strains of prion disease agents, and the accumulation of protein deposits within brain parenchyma.
State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, including research techniques now likely to enjoy broader application for the more common proteinopathies, such as Alzheimer's and Parkinson's diseases.

Editors and affiliations

  • Harry F. Baker
    • 1
  1. 1.Department of Experimental Psychology, MRC Comparative Cognition TeamSchool of Clinical Veterinary MedicineCambridge

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2001
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-924-7
  • Online ISBN 978-1-59259-134-3
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site