Vaccine Adjuvants

Preparation Methods and Research Protocols

  • Derek T. O’Hagan

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 42)

Table of contents

  1. Front Matter
    Pages i-x
  2. Robert Edelman
    Pages 1-27
  3. Duncan E. S. Stewart-Tull
    Pages 29-48
  4. Erik B. Lindblad
    Pages 49-63
  5. Rajesh K. Gupta, Bradford E. Rost
    Pages 65-89
  6. Derek T. O’ Hagan, Manmohan Singh
    Pages 91-103
  7. Charles W. Todd, Mark J. Newman
    Pages 121-136
  8. Gregory Gregoriadis, Brenda McCormack, Mia Obrenovic, Yvonne Perrie, Roghieh Saffie
    Pages 137-150
  9. Susan Gould-Fogerite, Raphael J. Mannino
    Pages 179-196
  10. Sarah C. Gilbert
    Pages 197-209
  11. Karin Lövgren-Bengtsson, Bror Morein
    Pages 239-258
  12. Charlotte Read Kensil
    Pages 259-271
  13. J. Terry Ulrich
    Pages 273-282
  14. David C. Neujahr, David S. Pisetsky
    Pages 299-313
  15. Gregory M. Glenn, Tanya Scharton-Kersten, Russell Vassell
    Pages 315-326
  16. Jason A. Neidleman, Gary Ott, Derek O’Hagan
    Pages 327-336
  17. Back Matter
    Pages 337-342

About this book


Adjuvants play a key role in controlling the efficacy of vaccines, through enhancing the immune response to vaccine antigens, including recombinant proteins, protein polysaccharide conjugates, synthetic peptides, or DNA. In Vaccine Adjuvants: Preparation Methods and Research Protocols, Derek T. O'Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, including suggestions why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. The methods, described in full detail, range from the simple mixing of an antigen with a preformed adjuvant, to a complex preparation process requiring the antigens to be physically associated, or entrapped within, an adjuvant formulation.
Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today's researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way. The use of the information in this book will promote the development of powerful new vaccines against infectious diseases and cancers, and may promote the development of products to ameliorate autoimmune disorders.

Editors and affiliations

  • Derek T. O’Hagan
    • 1
  1. 1.Chiron CorporationEmeryville

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Springer, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-735-9
  • Online ISBN 978-1-59259-083-4
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site