Hepatocellular Carcinoma

Methods and Protocols

  • Nagy A. Habib

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 45)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. The Clinical Problem

    1. Front Matter
      Pages 1-34
    2. Valery Usatoff, Nagy A. Habib
      Pages 3-20
    3. Stephen M. Riordan, Roger Williams
      Pages 21-34
  3. HCC Carcinogenesis

    1. Front Matter
      Pages 35-96
    2. Satoshi Ishido, Tsunenori Fujita, Hak Hotta
      Pages 37-55
    3. Carmen Vandelli, Francesco Renzo
      Pages 71-96
  4. Molecular and Biological Characteristics

  5. HCC Gene Therapy

    1. Front Matter
      Pages 175-269
    2. Shuichi Kaneko, Taiki Tamaoki
      Pages 177-187
    3. Ragai R. Mitry, Michael D. Kelly, Jian Zhao, Satoko Negishi, Marc R. Mansour, Nagy A. Habib
      Pages 207-220
    4. Yanjun Liu, Jian Zhao, Yang Lu, Jerzy Trojan, Mengchao Wu, Yajun Guo
      Pages 221-235
    5. Lixin Wei, Hao Wang, Yanjun Liu, Mengchao Wu, Yajun Guo
      Pages 237-246
    6. Andrei I. Chapoval, Gefeng Zhu, Lieping Chen
      Pages 247-255
    7. Fumihiko Kanai, Makoto Ohashi, Paola A. Marignani, Yasushi Shiratori, Hirofumi Hamada, Masao Omata
      Pages 257-269
  6. Clinical Protocol for P53 Gene Therapy for Liver Tumors

    1. Front Matter
      Pages 271-298
    2. Michael D. Kelly, Ragai R. Mitry, Nagy A. Habib
      Pages 273-298
  7. Back Matter
    Pages 299-302

About this book


Advances in molecular characterization and novel gene-isolation techniques have vigorously expanded our understanding of hepatocellular carcinoma (HCC), a form of liver cancer that affects one million people annually, and generated many new therapeutic possibilities. In Hepatocellular Carcinoma: Methods and Protocols, Nagy Habib and a team of basic and clinical researchers describe the wide variety of powerful new laboratory-based molecular methods currently being used for investigating and treating this disease. The book focuses on gene therapy approaches, including the use of such vectors as lipids, adenovirus, and baculovirus, and virus detection assessment using electron microscopy. It also provides preclinical and clinical data on the killing of cancer cells using tumor-suppressor genes, antisense compounds to growth factors, immunotherapy (remove gene), and virus-directed enzyme prodrug therapy. A perspective on future treatment of the failing liver is given, along with a clinical protocol for p53 gene therapy.
Hepatocellular Carcinoma: Methods and Protocols offers experimental and clinical investigators a rich source of both basic science and clinical information on today's optimal use of gene therapy to treat and manage patients suffering from hepatocellular carcinoma.

Editors and affiliations

  • Nagy A. Habib
    • 1
  1. 1.Liver Surgery SectionImperial College School of Medicine, Hammersmith HospitalLondonUK

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-785-4
  • Online ISBN 978-1-59259-079-7
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site