Diagnostic and Therapeutic Antibodies

  • Andrew J. T. George
  • Catherine E. Urch

Part of the Methods in Molecular Medicine book series (MIMM, volume 40)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Introduction

    1. Andrew J. T. George
      Pages 1-21
    2. Mary A. Ritter
      Pages 23-34
    3. Rakesh Verma, Ekaterini Boleti
      Pages 35-52
    4. Michael Johns
      Pages 53-62
  3. Antibodies in Medicine

    1. Ian T. W. Matthews
      Pages 73-84
    2. Martin J. Glennie, Jamie Honeychurch, Ruth R. French, Alison L. Tutt
      Pages 85-97
    3. Richard Smith
      Pages 99-114
    4. Peter C. Taylor
      Pages 115-139
    5. Denise L. Faustman
      Pages 141-156
    6. H. Barbaros Oral, Cezmi A. Akdis
      Pages 157-178
    7. A. Michael Peters
      Pages 179-192
    8. Gail Rowlinson-Busza
      Pages 193-207
    9. David J. Newman
      Pages 209-225
  4. Ethics and Industry

    1. William M. Brown
      Pages 227-241
    2. Geoff Hale, Herman Waldmann
      Pages 243-266
  5. Production and Purification

    1. J’ona Freysd’ottir
      Pages 267-279
    2. Patrick Harrison, Geoff Hale
      Pages 295-301
    3. Pru Bird, Geoff Hale
      Pages 303-307
    4. Jenny Phillips, Patrick Harrison, Geoff Hale
      Pages 309-312
    5. Kuldip Bhamra, Patrick Harrison, Jenny Phillips, Geoff Hale
      Pages 313-317
    6. Jenny Phillips, Geoff Hale
      Pages 319-323
  6. Modification of Antibodies

  7. Application of Antibodies in Vitro

    1. Bill Jordan
      Pages 373-379
    2. Abdulhamid A. Al-Tubuly
      Pages 391-405
    3. Paul F. McKay
      Pages 407-414
    4. Susan Van Noorden
      Pages 415-437
    5. Catherine E. Sarraf
      Pages 439-452
  8. Antibody Engineering

    1. Rakesh Verma
      Pages 453-459
    2. Michael Johns, Donald B. Palmer
      Pages 461-470
  9. Back Matter
    Pages 471-477

About this book


The use of monoclonal antibodies in treating disease has long held tantalizing promise, and the recent explosion of successful clinical trials-leading to the licensing of novel antibody-based therapeutic agents-has clearly demonstrated the power of recombinant antibody engineering, and greatly rejuvenated interest in their emergent clinical applications. In Diagnostic and Therapeutic Antibodies, a team of experts comprehensively reviews the theoretical and practical aspects of applying antibodies in both the laboratory and clinic. For general understanding, the book thoroughly introduces the basic science of the antibody molecule, including its structure and generation. Several novel in vivo applications of therapeutic antibodies are then presented to illustrate their special value in varied clinical settings. For those new to the field, there are readily reproducible methods for generating and purifying antibodies and for modifying them for clinical application, including how to measure their affinity and immunoactivity, and how to employ them in staining procedures and in a variety of in vitro assays.
Timely and comprehensive, Diagnostic and Therapeutic Antibodies offers today‚s clinical researchers a concise introduction to the field, as well as a highly useful compendium of practical protocols that will greatly facilitate the application of these powerful new diagnostic and therapeutic agents.

Editors and affiliations

  • Andrew J. T. George
    • 1
  • Catherine E. Urch
    • 2
  1. 1.Department of ImmunologyImperial College School of Medicine, Hammersmith HospitalLondonUK
  2. 2.Department of PharmacologyUniversity CollegeLondonUK

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-798-4
  • Online ISBN 978-1-59259-076-6
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site