Extracellular Matrix Protocols

  • Charles H. Streuli
  • Michael E. Grant

Part of the Methods in Molecular Biology™ book series (MIMB, volume 139)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Biochemistry of Extracellular Matrix

    1. Front Matter
      Pages xv-xv
    2. Richard R. Wilson, Neil J. Bulleid
      Pages 1-9
  3. Biophysics of Extracellular Matrix Proteins

    1. Front Matter
      Pages 49-49
    2. Trevor J. Sims, Nicholas C. Avery, Allen J. Bailey
      Pages 11-26
    3. Timothy Hardingham, Philip Gribbon
      Pages 83-93
    4. Roger S. Meadows, David F. Holmes, Chris J. Gilpin, Karl E. Kadler
      Pages 95-109
    5. Michael J. Sherratt, Helen K. Graham, Cay M. Kielty, David F. Holmes
      Pages 119-132
  4. Molecular Biology of Extracellular Matrix Genes

    1. Front Matter
      Pages 133-133
    2. Michael D. Briggs
      Pages 133-145
    3. Emilio Hirsch, Mara Brancaccio, Fiorella Altruda
      Pages 147-178
    4. Francesco Ramirez, Friedrich Laub, Hideaki Sumiyoshi
      Pages 179-185
    5. Noriyuki Tsumaki, Ying Liu, Yoshihiko Yamada, Paul Krebsbach
      Pages 187-195
    6. Kyonggeun Yoon, Vitali Alexeev
      Pages 197-208
  5. Cell Biology of the Extracellular Matrix

    1. Front Matter
      Pages 209-209
    2. Christopher S. Chen, Emanuele Ostuni, George M. Whitesides, Donald E. Ingber
      Pages 209-219
    3. José MarÍa Frade, Alfredo Rodriguez Tébar
      Pages 257-264
    4. Emma E. Frost, Richard Milner, Charles ffrench-Constant
      Pages 265-278
    5. Martin J. Humphries
      Pages 279-285
    6. Ronda E. Schreiber, Anthony Ratcliffe
      Pages 301-309
    7. Patricia Simon-Assmann, Michèle Kedinger
      Pages 311-319
    8. Paola Spessotto, Emiliana Giacomello, Roberto Perris
      Pages 321-343
  6. Back Matter
    Pages 359-370

About this book


It is now widely accepted that much of the dynamic function of cells and tissues is regulated from outside the cell by the extracellular matrix (ECM). In Extracellular Matrix Protocols, leading bench-top experimentalists from around the world present in a proven format their state-of-the-art methods for probing the extracellular matrix, its mechanisms of assembly, and how it influences cell behavior. These carefully detailed biochemical, biophysical, molecular biological, and cell biological techniques have been optimized for the study ECM structure and assembly, the mechanisms of cell-ECM interactions, and the molecular genetics of ECM proteins and defects in human disease, and bring to a wider audience a range of highly sophisticated methods that have hitherto been difficult even for a few specialized laboratories.
Cutting-edge and highly practical, Extracellular Matrix Protocols offers today's ECM researchers a gold-standard collection of powerful, readily reproducible methods to investigate the extracellular matrix and the altered cell-ECM interactions that play so important a role in human health and disease.

Editors and affiliations

  • Charles H. Streuli
    • 1
  • Michael E. Grant
    • 1
  1. 1.The Wellcome Trust Centre for Cell-Matrix Research, School of Biological SciencesUniversity of ManchesterManchesterUK

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-624-6
  • Online ISBN 978-1-59259-063-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site