Therapeutic Applications of Ribozymes

  • Kevin J. Scanlon

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 11)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Philip Hendry, Trevor J. Lockett, Maxine J. McCall
    Pages 1-15
  3. Arnold Hampel
    Pages 17-28
  4. Lun-Quan Sun, Wayne Gerlach, Geoff Symonds
    Pages 51-64
  5. Eric M. Poeschla, Mang Yu, Mark C. Leavitt, Flossie Wong-Staal
    Pages 65-82
  6. Jun Ohkawa, Yutaka Takebe, Kazunari Taira
    Pages 83-95
  7. Gerd Hobom, Annette Menke
    Pages 97-110
  8. Fritz von Weizsäcker, Hubert E. Blum, Jack R. Wands
    Pages 111-117
  9. Glenn H. Cantor
    Pages 119-129
  10. Akira Irie, ierry Tsai, Mohammed Kashani-Sabet
    Pages 153-168
  11. Tsukasa Ohkawa, Mohammed Kashani-Sabet
    Pages 169-192
  12. Hiroshi Kijima, David Y. Bouffard, Kevin J. Scanlon
    Pages 193-208
  13. Alex W. Tong, Yu-An Zhang, John Nemunaitis, Gabriele Mues
    Pages 209-222
  14. Toshiya Suzuki, Lisa D. Curcio, Jerry Tsai, Mohammed Kashani-Sabet
    Pages 223-239
  15. Gunhild M. Mælandsmo, Inge Kjønniksen, Eivind Hovig, Kevin J. Scanlon, Øystein Fodstad
    Pages 241-260
  16. Mouldy Sioud
    Pages 261-278
  17. Lance H. Leopold, Scott K. Shore, Ramana M. V. Reddy, E. Premkumar Reddy
    Pages 279-292
  18. Hiromichi Matsushita, Hiroyuki Kobayashi, Masahiro Kizaki, Yasuo Ikeda
    Pages 293-310
  19. Frank Czubayko, Anke M. Schulte, Anton Wellstein
    Pages 311-328
  20. Thale C. Jarvis, Dennis Macejak, Larry Couture
    Pages 329-339
  21. S. Petter Lyngstadaas, Brian S. Sproat, Martina Blaschke, Janos Ludwig, Thomas Rupp, Hans P. Prydz
    Pages 371-386
  22. Katalin Karikó, Elliot S. Barnathan
    Pages 427-438
  23. P. Kamath, E. J. Shillitoe
    Pages 439-446
  24. Back Matter
    Pages 447-462

About this book


In Therapeutic Applications of Ribozymes, expert laboratory scientists describe in detail their methodologies for constructing ribozymes designed to elucidate the role of specific genes as key routes to the development of novel therapies for a wide variety of diseases. The authors review the many sites targeted with ribozymes in various diseases and provide specific accounts of the practical techniques required for the proper use of ribozymes in these systems. Their cutting-edge protocols demonstrate how to achieve ribozyme expression in distinct cellular systems, the preparation and use of high-efficiency ribozyme DNA or RNA delivery, and the studies required to prove the efficacy of ribozyme-mediated inhibition, with its concomitant effect on phenotypic parameters.

Therapeutic Applications of Ribozymes contains all the practical detail necessary to realize the high promise of ribozyme technology as a significant, widely used methodology. Focused on ribozyme targets and the novel associated technology, the book immediately becomes the leading resource for all those seeking to transform this new category of therapeutic agent into efficacious clinical practice.

Editors and affiliations

  • Kevin J. Scanlon
    • 1
  1. 1.Berlex BiosciencesRichmond

Bibliographic information

  • DOI
  • Copyright Information Humana Press 1998
  • Publisher Name Springer, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-477-8
  • Online ISBN 978-1-59259-595-2
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site