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Analysis of Psychiatric Drugs

  • Alan A. Boulton
  • Glen B. Baker
  • Ronald T. Coutts
Book

Part of the Neuromethods book series (NM, volume 10)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Stephen H. Curry, Oliver Y-P Hu, Robin Whelpton
    Pages 1-31
  3. Trevor R. Norman, Graham D. Burrows
    Pages 33-64
  4. Larry Tune
    Pages 219-239
  5. Dennis E. Schmidt, Michael H. Ebert
    Pages 241-301
  6. Graham R. Jones, Peter P. Singer
    Pages 303-325
  7. Andrew J. Greenshaw, Tuong Van Nguyen, David J. Sanger
    Pages 379-427
  8. Hans Schoemaker, Salomon Z. Langer
    Pages 429-472
  9. Pier A. Borea, Thomas A. Hamor, Ian L. Martin
    Pages 473-531
  10. Back Matter
    Pages 533-547

About this book

Introduction

In this volume, we hope to cover the malor techniques that are presently being used to analyze the actions of drugs used in psyc- atry. The contributors of the chapters are active researchers who have considerable practical experience with the techniques they are describing, and the emphasis in the chapters is on three types of psychiatric drugs, namely antidepressants, antipsychotics, and anxiolytics. The first chapter, by Curry and Yu, discusses protein binding of psychotropic drugs, with special reference to equilibrium ana- sis as the method of assessment and to lipophilicity correlations. Since many of the drugs used in treating psychiatric disorders are bound extensively to protein, this aspect is of great importance with regard to their therapeutic actions and toxicity, Basic mat- matical models, techniques for the study of protein binding, molecular aspects of protein binding, binding in relation to lipophilicity, indirect approaches to measurement of the fraction of drug bound, the function of protein binding, and tissue binding are among the topics discussed. Chapter 2, by Norman and B- rows, deals with the principles of isotope derivative assays and their applications to antidepressants and antipsychotics; extensive protocols are provided. The third chapter, by Cooper, deals with analysis by gas-liquid chromatography. Sample collection and storage, extraction procedures, column selection, use of internal standards, types of detectors, techniques of application, and - plications to specific drugs are among the topics discussed.

Editors and affiliations

  • Alan A. Boulton
    • 1
  • Glen B. Baker
    • 2
  • Ronald T. Coutts
    • 2
  1. 1.University of SaskatchewanSaskatoon
  2. 2.Unrversity of AlbertaEdmonton

Bibliographic information

  • DOI https://doi.org/10.1385/0896031217
  • Copyright Information Humana Press 1988
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-121-0
  • Online ISBN 978-1-59259-615-7
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site