Biology, Computing, and the History of Molecular Sequencing

From Proteins to DNA, 1945–2000

  • Miguel García-Sancho

Part of the Science, Technology and Medicine in Modern History book series (STMMH)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Introduction: An Historical Approach to Sequencing

    1. Miguel García-Sancho
      Pages 1-16
  3. Emergence: Frederick Sanger’s Pioneering Techniques (1943–1977)

  4. Mechanisation — 1: Computing and the Automation of Sequence Reconstruction (1962–1987)

    1. Front Matter
      Pages 65-69
  5. Mechanisation — 2: The Sequencer and the Automation of Sequence Construction (1980–2000)

    1. Front Matter
      Pages 115-118
    2. Miguel García-Sancho
      Pages 119-143
    3. Miguel García-Sancho
      Pages 144-168
  6. Conclusions: A Long History of Practices

    1. Miguel García-Sancho
      Pages 169-177
  7. Back Matter
    Pages 178-242

About this book


Sequencing is often associated with the Human Genome Project and celebrated achievements concerning the DNA molecule. However, the history of this practice comprises not only academic biology, but also the world of computer-assisted information management. The book uncovers this history, qualifying the hype and expectations around genomics.


biology DNA protein sequencing

Authors and affiliations

  • Miguel García-Sancho
    • 1
  1. 1.Spanish National Research Council (CSIC)MadridSpain

Bibliographic information

  • DOI
  • Copyright Information Palgrave Macmillan, a division of Macmillan Publishers Limited 2012
  • Publisher Name Palgrave Macmillan, London
  • eBook Packages Palgrave History Collection
  • Print ISBN 978-1-349-32122-3
  • Online ISBN 978-0-230-37093-7
  • Buy this book on publisher's site