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Cytochrome P450

Structure, Mechanism, and Biochemistry

  • Textbook
  • © 2005

Overview

Editors:
  1. Paul R. Ortiz de Montellano

    1. Department of Pharmaceutical Chemistry, University of California, San Francisco

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xx
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  2. Models and Mechanisms of Cytochrome P450 Action

    • John T. Groves
    Pages 1-43

  3. Computational Approaches to Cytochrome P450 Function

    • Sason Shaik, Samuël P. De Visser
    Pages 45-85

  4. Structures of Cytochrome P450 Enzymes

    • Thomas L. Poulos, Eric F. Johnson
    Pages 87-114

  5. Electron Transfer Partners of Cytochrome P450

    • Mark J. I. Paine, Nigel S. Scrutton, Andrew W. Munro, Aldo Gutierrez, Gordon C. K. Roberts, C. Roland Wolf
    Pages 115-148

  6. Activation of Molecular Oxygen by Cytochrome P450

    • Thomas M. Makris, Ilia Denisov, Ilme Schlichting, Stephen G. Sligar
    Pages 149-182

  7. Substrate Oxidation by Cytochrome P450 Enzymes

    • Paul R. Ortiz de Montellano, James J. De Voss
    Pages 183-245

  8. Inhibition of Cytochrome P450 Enzymes

    • Maria Almira Correia, Paul R. Ortiz de Montellano
    Pages 247-322

  9. Induction of Cytochrome P450 Enzymes

    • Susanne N. Williams, Elizabeth Dunham, Christopher A. Bradfield
    Pages 323-346

  10. Hormonal Regulation of Liver Cytochrome P450 Enzymes

    • David J. Waxman, Thomas K. H. Chang
    Pages 347-376

  11. Human Cytochrome P450 Enzymes

    • F. Peter Guengerich
    Pages 377-530

  12. Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids

    • Jorge H. Capdevila, Vijaykumar R. Holla, John R. Falck
    Pages 531-551

  13. Cytochrome P450s in Plants

    • Kirsten Annette Nielsen, Birger Lindberg Møller
    Pages 553-583

  14. The Diversity and Importance of Microbial Cytochromes P450

    • Steven L. Kelly, Diane E. Kelly, Colin J. Jackson, Andrew G. S. Warrilow, David C. Lamb
    Pages 585-617

  15. Back Matter

    Pages 619-689
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Keywords

About this book

Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.

Reviews

Praise for the Second Edition: `Professor Paul R. Ortiz de Montellano (known in some databases as 'P.R.O. Demontellano' has spared no effort in the preparation of this major work. All 15 chapters and the two appendices were written by experts of high international reputation. The content is structured into four parts arranged clearly and logically. As a result, the reader goes from the table of contents to the main body of the book with a favourable impression of clarity and comprehensiveness. Needless to say, this impression is verified throughout the chapters.'
ISSX: International Society for Study of Xenobiotics (October 1996)
`The 1986 edition of Cytochrome P450: Structure, Mechanism, and Biochemistry is probably the most frequently cited single source of information about the subject...Ortiz de Montellano has now produced a second edition with 15 new chapters. In my estimation, he has again succeeded in bringing the P450 field into sharp focus.'
Science, 271 (March 1996)

Editors and Affiliations

  • Department of Pharmaceutical Chemistry, University of California, San Francisco

    Paul R. Ortiz de Montellano

Bibliographic Information

  • Book Title: Cytochrome P450

  • Book Subtitle: Structure, Mechanism, and Biochemistry

  • Editors: Paul R. Ortiz de Montellano

  • DOI: https://doi.org/10.1007/b139087

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag US 2005

  • Hardcover ISBN: 978-0-306-48324-0Published: 21 December 2004

  • Softcover ISBN: 978-1-4419-3443-7Published: 29 October 2010

  • eBook ISBN: 978-0-387-27447-8Published: 05 February 2007

  • Edition Number: 3

  • Number of Pages: XX, 690

  • Topics: Pharmacy, Biochemistry, general, Pharmacology/Toxicology

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