DNA Methylation and Cancer Therapy

  • Moshe Szyf

Part of the Medical Intelligence Unit book series (MIUN)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Aharon Razin
    Pages 1-12
  3. Keith D. Robertson
    Pages 13-30
  4. Melanie Ehrlich, Guanchao Jiang
    Pages 31-41
  5. Wolfgang A. Schulz, Hans-Helge Seifert
    Pages 42-58
  6. Jeremy R. Jass, Vicki L. J. Whitehall, Joanne Young, Barbara A. Leggett
    Pages 59-68
  7. Alain Niveleau, Chandrika Piyathilake, Adriana de Capoa, Claudio Grappelli, Jean-Marc Dumollard, Lucien Frappart et al.
    Pages 85-106
  8. Susan H. Wei, Timothy T. -C. Yip, Chuan-Mu Chen, Tim H. -M. Huang
    Pages 107-116
  9. Carolina Haefliger, Sabine Maier, Alexander Olek
    Pages 117-124
  10. Nancy Detich, Moshe Szyf
    Pages 125-141
  11. Anna Reale, Giuseppe Zardo, Maria Malanga, Jordanka Zlatanova, Paola Caiafa
    Pages 142-155
  12. Moshe Szyf, Paul M. Campbell, Nancy Detich, Jing Ni Ou, Stefan Hamm, Veronica Bovenzi
    Pages 156-177
  13. Katherine L. Seley, Sylvester L. Mosley
    Pages 178-186
  14. Gregory K. Reid, A. Robert MacLeod
    Pages 187-204
  15. Moshe Szyf
    Pages 230-233
  16. Back Matter
    Pages 235-239

About this book


NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo­ Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me­ thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat­ terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac­ tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.


DNA Expression Microarray Purine enzymes gene expression gene therapy protein proteins transcription tumorigenesis

Authors and affiliations

  • Moshe Szyf
    • 1
  1. 1.Department of Pharmacology and TherapeuticsMcGill UniversityMontrealCanada

Bibliographic information