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  • Conference proceedings
  • © 2005

Biocombinatorial Approaches for Drug Finding

Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 51)

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Table of contents (12 papers)

  1. Front Matter

    Pages I-XVIII
  2. Sources of Polyketides and Non-Ribosomal Peptides

    • S. Donadio, E. Busti, P. Monciardini, R. Bamonte, P. Mazza, M. Sosio et al.
    Pages 19-41
  3. Polyketide Synthases: Mechanisms and Models

    • K. J. Weissman
    Pages 43-78
  4. Prerequisites for Combinatorial Biosynthesis: Evolution of Hybrid NRPS/PKS Gene Clusters

    • B. Shen, M. Chen, Y. Cheng, L Du, D. J. Edwards, N. P. George et al.
    Pages 107-126
  5. Glycosyltransferases and Other Tailoring Enzymes as Tools for the Generation of Novel Compounds

    • A. Bechthold, G. Weitnauer, A. Luzhetskyy, M. Berner, C. Bihlmeier, R. Boll et al.
    Pages 147-163
  6. Enzymatic Incorporation of Halogen Atoms into Natural Compounds

    • E. Kling, C. Schmid, S. Unversucht, T. Wage, S. Zehner, K. -H. van Pee
    Pages 165-194
  7. From Glucose to Antibiotics: What Controls the Fluxes?

    • J. Nielsen, A. Eliasson
    Pages 195-214
  8. Precursor-Directed Biosynthesis for the Generation of Novel Glycopetides

    • E. Stegmann, D. Bischoff, C. Kittel, S. Pelzer, O. Puk, J. Recktenwald et al.
    Pages 215-232
  9. Back Matter

    Pages 285-288

About this book

Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Foundation Workshop 51 was to provide a forum for an open exchange on perspectives and limitations of biocombinatorial synthesis and the significance of this technology for future drug discovery in  light of this challenge. Experts from academia and industry provided contributions covering: the significance of natural compounds for state-of-the-art drug discovery; the underlying basic principle for the biosynthesis of highly complex compounds; and the scope and limitations of combinatorial biosynthesis regarding formation, identification, optimisation, isolation and manufacturing of novel biologically active entities.

Editors and Affiliations

  • Microbiology/Biotechnology, Eberhard-Karls-Universität Tübingen, Tübingen, Germany

    W. Wohlleben

  • Corporate Research, Research Center Europe, Proteinchemistry, Schering AG, Berlin, Germany

    T. Spellig, B. Müller-Tiemann

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access