Biocombinatorial Approaches for Drug Finding

  • W. Wohlleben
  • T. Spellig
  • B. Müller-Tiemann

Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 51)

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. S. Donadio, E. Busti, P. Monciardini, R. Bamonte, P. Mazza, M. Sosio et al.
    Pages 19-41
  3. K. J. Weissman
    Pages 43-78
  4. B. Shen, M. Chen, Y. Cheng, L Du, D. J. Edwards, N. P. George et al.
    Pages 107-126
  5. A. Bechthold, G. Weitnauer, A. Luzhetskyy, M. Berner, C. Bihlmeier, R. Boll et al.
    Pages 147-163
  6. E. Kling, C. Schmid, S. Unversucht, T. Wage, S. Zehner, K. -H. van Pee
    Pages 165-194
  7. J. Nielsen, A. Eliasson
    Pages 195-214
  8. E. Stegmann, D. Bischoff, C. Kittel, S. Pelzer, O. Puk, J. Recktenwald et al.
    Pages 215-232
  9. Back Matter
    Pages 285-288

About these proceedings

Introduction

Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Foundation Workshop 51 was to provide a forum for an open exchange on perspectives and limitations of biocombinatorial synthesis and the significance of this technology for future drug discovery in  light of this challenge. Experts from academia and industry provided contributions covering: the significance of natural compounds for state-of-the-art drug discovery; the underlying basic principle for the biosynthesis of highly complex compounds; and the scope and limitations of combinatorial biosynthesis regarding formation, identification, optimisation, isolation and manufacturing of novel biologically active entities.

Keywords

Combinatorial Biosynthesis Diversity Nonribosomal peptides Polyketides Proteome drug drug discovery genome natural product protein research synthesis

Editors and affiliations

  • W. Wohlleben
    • 1
  • T. Spellig
    • 2
  • B. Müller-Tiemann
    • 2
  1. 1.Microbiology/BiotechnologyEberhard-Karls-Universität TübingenTübingenGermany
  2. 2.Corporate Research, Research Center Europe, ProteinchemistrySchering AGBerlinGermany

Bibliographic information

  • DOI https://doi.org/10.1007/b138552
  • Copyright Information Springer Berlin Heidelberg 2005
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-22092-3
  • Online ISBN 978-3-540-27055-3
  • Series Print ISSN 0947-6075
  • About this book