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Animal Models of T Cell-Mediated Skin Diseases

  • T. Zollner
  • H. Renz
  • K. Asadullah

Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 50)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. M. Pasparakis
    Pages 1-26
  3. M. Wegmann, H. Renz
    Pages 69-87
  4. R. O. Williams
    Pages 89-117
  5. M. F. Neurath
    Pages 119-132
  6. T. Brzoska, T. A. Luger
    Pages 133-166
  7. U. Niesner, F. Hardung, A. Scheffold, A. Radbruch
    Pages 175-191
  8. T. M. Zollner, F. H. Igney, K. Asadullah
    Pages 255-275
  9. Back Matter
    Pages 293-296

About these proceedings

Introduction

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

Keywords

Animal Models of Skin Diseases Asthma Atopic Dermatitits Contact dermatitis Gene-modified mice Psoriasis genes

Editors and affiliations

  • T. Zollner
    • 1
  • H. Renz
    • 2
  • K. Asadullah
    • 1
  1. 1.Corporate Research Business Area DermatologySchering AGBerlinGermany
  2. 2.Department of Clinical Chemistry and Molecular DiagnosticsHospital of the Philipps-UniversityMarburgGermany

Bibliographic information

  • DOI https://doi.org/10.1007/b138119
  • Copyright Information Springer Berlin Heidelberg 2005
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-21067-2
  • Online ISBN 978-3-540-26811-6
  • Series Print ISSN 0947-6075
  • Buy this book on publisher's site