Skip to main content
  • Book
  • © 2005

Biophysical Aspects of Transmembrane Signaling

  • The first book to describe transmembrane signalling in cells from a physical and biochemical perspective

  • Especially addresses biophysicists with a biological background

Part of the book series: Springer Series in Biophysics (BIOPHYSICS, volume 8)

Buying options

eBook USD 219.00
Price excludes VAT (USA)
  • ISBN: 978-3-540-26511-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 279.99
Price excludes VAT (USA)
Hardcover Book USD 249.99
Price excludes VAT (USA)

This is a preview of subscription content, access via your institution.

Table of contents (10 chapters)

  1. Front Matter

    Pages I-XVIII
  2. The Impact of Environmental Signals on the Growth and Survival of Human T Cells

    • Fernando A. Arosa, Ana M. Fonseca, Susana G. Santos, Nuno L. Alves
    Pages 1-32
  3. Novel Single Cell Fluorescence Approaches in the Investigation of Signaling at the Cellular Level

    • Péter Nagy, György Vereb, Janine N. Post, Elza Friedländer, János Szölloősi
    Pages 33-70
  4. Non-Random Patterns of Membrane Proteins and Their Roles in Transmembrane Signaling

    • Andrea Bodnár, György Vámosi, Katalin Tóth, Attila Jenei, László Mátyus, Sándor Damjanovich
    Pages 71-95
  5. Transmembrane Signals Mediated by IL-2 and IL-15 Control the Life and Death of Lymphocytes

    • Thomas A. Waldmann, Sigrid Dubois, Jürgen Müller, Carolyn Goldman, Sándor Damjanovich
    Pages 97-121
  6. Single-Molecule Imaging of Diffusion, Recruitment, and Activation of Signaling Molecules in Living Cells

    • Akihiro Kusumi, Hideji Murakoshi, Kotono Murase, Takahiro Fujiwara
    Pages 123-152
  7. Chemokine Signaling: The Functional Importance of Stabilizing Receptor Conformations

    • José Miguel Rodríguez-Frade, Antonio Serrano, Carlos Martínez-A, Mario Mellado
    Pages 153-170
  8. Signaling and Reverse Signaling in the Tumor Necrosis Factor/TNF Receptor System

    • Ernő Duda, Tünde Nagy, Daniela N. Männel, Günther Eissner
    Pages 171-209
  9. Histamine Receptors and Signaling

    • Hargita Hegyesi, Zsuzsa Darvas, Robin L. Thurmond, András Falus
    Pages 265-291
  10. Signal Transduction by Ion Channels in Lymphocytes

    • Zoltán Varga, Rezsoő Gáspár
    Pages 293-315
  11. Back Matter

    Pages 317-321

About this book

Transmembrane signaling is one of the most significant cell biological events in the life and death of cells in general and lymphocytes in particular. Until recently biochemists and biophysicists were not accustomed to thinking of these processes from the side of a high number of complex biochemical events and an equally high number of physical changes at molecular and cellular levels at the same time. Both types of researchers were convinced that their findings are the most decisive, having higher importance than the findings of the other scientist population. Both casts were wrong. Life, even at cellular level, has a number of interacting physical and biochemical mechanisms, which finally build up the creation of an "excited" cell that will respond to particular signals from the outer or inner world.

This book handles both aspects of the signalling events, and in some cases tries to unify our concepts and help understand the signals that govern the life and death of our cells. Not only the understanding, but also the interference (e.g. medication) may depend on the full knowledge of both sides.

These above statements are supported by the application of highly diverse physical and biochemical technologies demonstrated and explained by experts who are pioneers of their particular scientific field.


  • Activation
  • Biophysikalische Techniken
  • Phosphorylierung
  • Transmembrane Signalübertragung
  • Zellen
  • biophysical techniques
  • cells
  • fluorescence
  • imaging
  • phosphorylation
  • regulation
  • signal transduction
  • transmembrane signaling

Editors and Affiliations

  • Department of Biophysics and Cell Biology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

    Sandor Damjanovich

About the editor

Sándor Damjanovich initially studied medicine, and after he obtained his MD, he reoriented his focus in sciences and studied physics. After obtaining his three degrees (MD, Ph.D. and D.Sc) in Hungary, he travelled around the world studying and doing research in spectroscopy of proteins, molecular and cell biology of transmembrane signalling, and different aspects of membrane biophysics. While most of the time he preferentially applied luminescence methods, he also used other methods of investigation including flow cytometry, resonance energy transfer, steady state and time resolved fluorescence and phosphorescence spectroscopy, and most recently scanning force microscopy and near field optical microscopy in order to study cell surface phenomena. He and his co-workers have described a number of molecular patterns at the membrane of lymphocytes and other cells and are proponents of the belief that dynamic cell surface patterns and receptor superstructures govern immune processes and pharmacological interactions at the plasma membrane.

As a recipient of several major fellowships and visiting professorships, he has spent more than two years at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, as well as extended visits in the United States (NIH, FDA and at the University of California in San Francisco). He is a member of the Hungarian Academy Sciences (currently the President of the Department of Biology of the Academy) and is also a member of EMBO. He has received many awards including the Széchenyi Prize and the Szilárd Leó Professorial Stipend. He is the author of over 250 publications and several books, among others on Mobility and Proximity of Macromolecules in Biological Membranes (CRC Press).

Sándor DAMJANOVICH has been a Full Professor in the Department of Biophysics and Cell Biology, University of Debrecen, Hungary, since 1972.

Bibliographic Information

  • Book Title: Biophysical Aspects of Transmembrane Signaling

  • Editors: Sandor Damjanovich

  • Series Title: Springer Series in Biophysics

  • DOI:

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2005

  • Hardcover ISBN: 978-3-540-25064-7

  • Softcover ISBN: 978-3-642-06411-1

  • eBook ISBN: 978-3-540-26511-5

  • Series ISSN: 0932-2353

  • Series E-ISSN: 1868-2561

  • Edition Number: 1

  • Number of Pages: XVIII, 322

  • Number of Illustrations: 23 b/w illustrations, 18 illustrations in colour

  • Topics: Biophysics, Cell Biology, Biochemistry

Buying options

eBook USD 219.00
Price excludes VAT (USA)
  • ISBN: 978-3-540-26511-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 279.99
Price excludes VAT (USA)
Hardcover Book USD 249.99
Price excludes VAT (USA)