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  • Book
  • © 2005

St. John's Wort and its Active Principles in Depression and Anxiety

Birkhäuser
  • Comprehensive overview of the available data for Hypericum extracts

  • International authorship

  • Includes supplementary material: sn.pub/extras

Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (13 chapters)

  1. Front Matter

    Pages I-VIII
  2. Introduction and historical overview

    • Walter E. Müller
    Pages 1-4
  3. Phytochemistry

    • Kurt Hostettmann, Jean-Luc Wolfender
    Pages 5-20
  4. Effects on transmitter uptake and their cellular and molecular basis

    • Kristina Treiber, Walter E. Müller
    Pages 31-46
  5. Modulation of neurotransmitter release and metabolism

    • Jan Kehr, Sven Ove Ögren, Takashi Yoshitake
    Pages 47-58
  6. Efficacy in behavioural models of antidepressant activity

    • Carla Gambarana, Daniela Giachetti
    Pages 59-71
  7. Pharmacokinetics and biopharmaceuticals

    • Mario Wurglics, Manfred Schubert-Zsilavecz
    Pages 99-121
  8. Clinical efficacy in depression

    • Siegfried Kasper
    Pages 123-131
  9. Side effects and drug interactions

    • Volker Schulz, Andreas Johne
    Pages 145-160
  10. Endocrinology of St. John’s Wort extract

    • Michael Franklin
    Pages 161-181
  11. Back Matter

    Pages 183-188

About this book

Hypericum extract preparations are used extensively in many countries to treat mildly to moderately depressed patients. While this was based previously on traditional experience, extensive research over the last 10 years has given a broad preclinical and clinical basis to justify the use of Hypericum as an antidepressant. This book reviews the available data related to the biochemical, functional, and behavioural pharmacology of Hypericum and its active constituents. The clinical chapters overview the evidenced basis for its use as an antidepressant, initial data in anxiety and somatoform disorders, and the site effect profile of Hypericum and its possible relevant drug interactions. The known pharmacokinetics of the relevant constituents and the biopharmaceutical quality of commercially available Hypericum preparations are also discussed.

Reviews

From the reviews:

...this book presents an excellent account of experimental as well as clinical research that has been done on St. John's wort. Not only have the authors been successful in presenting up-to-date information on many important topics but they have succesfully discussed the pros and cons of many conclusions. (Journal of Medicinal Chemistry)

“The book under discussion here comprises 13 chapters providing comprehensive information on all relevant aspects regarding both the medical and the pharmaceutical appraisal of this herbal antidepressant. … represents an excellent compilation of the results of research done on St. John’s wort. All important aspects are taken into consideration with constant quality. The text of the book is of reasonable comprehensibility. The figures and tables provided are useful and well organized. … I recommend this book to anybody interested in this topic.” (Eckart Eich, Economic Botany, Vol. 63 (4), 2009)

Editors and Affiliations

  • Pharmakologisches Institut für Naturwissenschaftler, Biozentrum Universität Frankfurt, Frankfurt, Germany

    Walter E. Müller

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access