Protein Misfolding, Aggregation, and Conformational Diseases

Part A: Protein Aggregation and Conformational Diseases

  • Vladimir N. Uversky
  • Anthony L. Fink

Part of the Protein Reviews book series (PRON, volume 4)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Structural and Conformational Prerequisites of Amyloidogenesis

    1. Vladimir N. Uversky, Ariel Fernández, Anthony L. Fink
      Pages 1-20
  3. The Generic Nature of Protein Folding and Misfolding

    1. Christopher M. Dobson
      Pages 21-41
  4. Relative Importance of Hydrophobicity, Net Charge, and Secondary Structure Propensities in Protein Aggregation

  5. Cytotoxic Intermediates in the Fibrillation Pathway: Aβ Oligomers in Alzheimer’s Disease as a Case Study

  6. Glycosaminoglycans, Proteoglycans, and Conformational Disorders

    1. Gregory J. Cole, I.-Hsuan Liu
      Pages 83-100
  7. Apolipoproteins in Different Amyloidoses

    1. Marcin Sadowski, Thomas Wisniewski
      Pages 101-122
  8. Oxidative Stress and Protein Deposition Diseases

    1. Joseph R. Mazzulli, Roberto Hodara, Summer Lind, Harry Ischiropoulos
      Pages 123-133
  9. Chaperone and Conformational Disorders

    1. Front Matter
      Pages 135-135
    2. Jennifer L. Wacker, Paul J. Muchowski
      Pages 137-164
  10. The Aggresome: Proteasomes, Inclusion Bodies, and Protein Aggregation

  11. Protein Aggregation, Ion Channel Formation, and Membrane Damage

  12. Visualization of Protein Deposits In Vivo

  13. Visualization of Protein Deposits In Vitro

    1. Front Matter
      Pages 285-285
    2. Harry LeVine III
      Pages 287-302
    3. Justin Legleiter, Tomasz Kowalewski
      Pages 315-334
  14. Animal and Cell Models of Human Neurodegenerative Disorders

    1. Front Matter
      Pages 345-345
    2. Eliezer Masliah, Leslie Crews
      Pages 371-408
  15. Back Matter
    Pages 409-419

About this book


Protein Misfolding, Aggregation, and Conformational Disease, is the first book to discuss significant achievements in protein structure-function relationships in the areas of biochemistry, molecular biology and molecular medicine. This volume summarizes recent achievements in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders. Research indicates that various human disorders, including most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. Protein Misfolding, Aggregation and Conformational Diseases is an ideal book for biochemists, protein scientists, immunologists, pharmaceutical scientists, and molecular and cellular biologists.


Aggregation Conformational Disease Misfolding Protein Uversky electron microscopy molecular biology proteoglycans

Editors and affiliations

  • Vladimir N. Uversky
    • 1
    • 2
  • Anthony L. Fink
    • 3
  1. 1.Department of Biochemistry and Molecular Biology Center for Computational Biology and BioinformaticsIndiana University School of MedicineIndianapolis
  2. 2.Institute for Biological InstrumentationRussian Academy of Sciences PushchinoMoscow RegionRussia
  3. 3.Department of Chemistry and BiochemistryUniversity of CaliforniaSanta CruzUSA

Bibliographic information