Experimental Models of Multiple Sclerosis

  • Ehud Lavi
  • Cris S. Constantinescu

Table of contents

  1. Front Matter
    Pages i-xii
  2. Experimental Allergic (Autoimmune) Encephalomyelitis (EAE)

    1. Front Matter
      Pages xiii-xiii
    2. Eli Ben-Chetrit, Stefan Brocke
      Pages 11-24
    3. Michael J. Day
      Pages 25-43
    4. James Garbern
      Pages 45-72
    5. Cris S Constantinescu, Brendan A Hilliard
      Pages 73-84
    6. Gennadij Raivich, Richard Banati
      Pages 109-131
    7. Nikos Evangelou, Cris S Constantinescu
      Pages 133-149
    8. Kelli Ryan, Stephen M Anderton
      Pages 201-243
    9. Johan van Beek, B. Paul Morgan
      Pages 245-267
    10. Xia Lin, Cris S Constantinescu
      Pages 269-281
    11. Cris S Constantinescu, David Baker
      Pages 283-311
    12. Hubertine Heremans, Alfons Billiau
      Pages 313-342
    13. Amy E. Lovett-Racke, Michael K. Racke
      Pages 343-361
    14. Andrzej R Glabinski, Richard M. Ransohoff
      Pages 363-377

About this book


Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.

Experimental Models of Multiple Sclerosis will be an important reference for neuroscientists, neurologists, immunologists, microbiologists (especially virologists) and pathologists (especially neuropathologists). Health professionals involved with MS, and medical students will also benefit from this book.


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Editors and affiliations

  • Ehud Lavi
    • 1
  • Cris S. Constantinescu
    • 2
  1. 1.Weill Medical College of Cornell UniversityNew York
  2. 2.Queen’s Medical CentreUniversity HospitalNottinghamUK

Bibliographic information

  • DOI https://doi.org/10.1007/b135502
  • Copyright Information Springer Science+Business Media, Inc. 2005
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-25517-0
  • Online ISBN 978-0-387-25518-7
  • About this book