Integration of Metabolism, Energetics, and Signal Transduction

Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease

  • Robert K. Ockner

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Prologue

    1. Front Matter
      Pages 1-1
  3. Fatty Acids, Mitochondria, and Signal Transduction: Integrated Control of Cell Proliferation, Injury, and Death

  4. Fatty Acids, Ketone Bodies, and Brain Metabolism: Implications for Neuronal Function and Alzheimer Disease

  5. Epilogue

    1. Front Matter
      Pages 359-359
  6. Back Matter
    Pages 369-387

About this book




Unifying Foundations in Cell Growth and Death, Cancer,

Atherosclerosis, and Alzheimer Disease




"Dr.  Ockner has written a fascinating and original book which explores potential metabolic links to neurodegeneration.  He takes a fresh look at metabolic pathways involving interaction between astrocyte and neuron that are important for brain health and may play a significant role in the pathogenesis of Alzheimer disease and other normal and pathological phenomena.  Dr. Ockner has a distinguished research career in fatty acid metabolism and the fatty acid binding proteins and writes with clarity upon this under-explored aspect of the brain in health and disease.  Not only is his book important for understanding links between systemic and cerebral metabolism in neurodegeneration, but  is a must read for scientists with an interest in the connection between metabolic pathways and brain function."

— Dr. Bruce Miller,

Professor of Neurology

Clinical director of the Memory and Aging Center

University of California, San Francisco


"I find this book to be a commendable and comprehensive undertaking as it encompasses an evaluation of a wide area of scientific research. Researchers working in lipid metabolism to those interested in mitochondrial energetics and in the mechanisms of signal transduction pathways in cancer and Alzheimer disease will benefit from this book."

—M.A.Q. Siddiqui,

Professor and Chairman of the Department of Anatomy and Cell Biology

SUNY Downstate, Brooklyn, NY

Robert K. Ockner,  M.D. is Professor of Medicine at the University of California, San Francisco, and is former Director of the UCSF Liver Center and Division of Gastroenterology. He and colleagues initially identified and characterized the cytosolic fatty acid binding proteins. He is a graduate of the Harvard Medical School and completed clinical and research training at Boston City Hospital, National Institutes of Health, and Massachusetts General Hospital.


Cover art by Sadie McFarlane


Alzheimer gene expression metabolism neurology proteins

Authors and affiliations

  • Robert K. Ockner
    • 1
  1. 1.University of California, San FranciscoSan Francisco

Bibliographic information

  • DOI
  • Copyright Information Springer Science + Business Media, Inc. 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-306-48471-1
  • Online ISBN 978-0-306-48529-9
  • Buy this book on publisher's site