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  • Book
  • © 2005

Hormonal Carcinogenesis IV

Editors:

  1. Jonathan J. Li

    1. Division of Etiology and Prevention of Hormonal Cancers, The University of Kansas Medical Center, Kansas City

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  2. Sara A. Li

    1. Division of Etiology and Prevention of Hormonal Cancers, The University of Kansas Medical Center, Kansas City

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Antonio Llombart-Bosch

    1. Departmento de Patologia, Facultad de Medicina y Odontologia, Valencia, Spain

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    You can also search for this editor in PubMed   Google Scholar

  • Covers a group of hormonally-associated cancers that present interesting challenges to clinicians and biomedical researchers

  • Addresses vital questions that impact our understanding of the causation, dependency, progression, resistance, and prevention of these types of cancers

  • Includes supplementary material: sn.pub/extras

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Table of contents (58 chapters)

  1. Front Matter

    Pages i-xxvi
    PDF

  2. Symposium Address

    1. Symposium Address

      • William R. Brinkley, David L. Stenoien, Thea Goepfert
      Pages 1-16

  3. State of the Art Lectures

    1. Front Matter

      Pages 17-17
      PDF

    2. Chromosomal Instability: A New Paradigm for Estrogen-induced Oncogenesis

      • Jonathan J. Li, Jeffrey Salisbury, Sara Antonia Li
      Pages 19-33

    3. The Molecular Pathogenesis of Human Prostate Cancer

      • William G. Nelson, Angelo M. DeMarzo, Theodore L. DeWeese, William B. Isaacs
      Pages 34-44

  5. Breast Cancer II: Mechanisms of Genomic Instability

    1. Front Matter

      Pages 85-85
      PDF

    2. c-Myc Deregulation Promotes a Complex Network of Genomic Instability

      • Sabine Mai, Amanda Guffei, Thierry Fest, J. Frederic Mushinski
      Pages 87-97

    3. Deregulation of Cyclin E and Genomic Instability

      • Charles H. Spruck, Adrian P. L. Smith, Susanna Ekholm Reed, Olle Sangfelt, Jaimie Keck, Heimo Strohmaier et al.
      Pages 98-105

  6. Breast and Prostate: Early In-Situ Lesions

    1. Front Matter

      Pages 119-119
      PDF

    3. Aromatase Overexpression: Effect of Tissue Estrogen on Phenotypic and Biochemical Changes in Aromatase Transgenic Mice

      • Rajeshwar Rao Tekmal, Nameer Kirma, Usha Mandava, Roopa Luthra
      Pages 130-140

    4. Prostate Epithelial Carcinogenesis: Putative and Controversial Precursor Lesions

      • Cristina Magi-Galluzzi, Angelo M. De Marzo
      Pages 141-150

  7. Promotion/Prevention of Hormone Cancers

    1. Front Matter

      Pages 151-151
      PDF

    2. Estrogen Can Prevent Breast Cancer by Mimicking the Protective Effect of Pregnancy

      • Satyabrata Nandi, Raphael C. Guzman, Gudmundur Thordarson, Lakshmanaswamy Rajkumar
      Pages 153-165

    3. Aromatase Inhibition and Breast Cancer

      • William R. Miller
      Pages 166-180
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About this book

It has been over a decade since the First International Symposium on Hormonal Carcinogenesis convened in 199 1. Since then, the field has rapidly expanded with considerable progress in both breast and prostate cancers; while ovarian and endometrial cancer have been hampered, in part, due to the absence of suitable hormone-mediated animal models. While knock-out, transgenic, and cell-culture systems have been extremely useful in identifying specific genelprotein alterations and the ensuing pathways affected, the precise molecular mechanisms whereby sex hormones elicit their oncogenic effects still remain elusive. Moreover, despite the considerable progress made in breast cancer research, the exact role of progestins in the presence or absence of estrogen in breast growth, differentiation, and malignant transformation is lacking. Elucidating the incipient molecular alterations in earlylpre-invasive lesions elicited by these hormones is a growing important focus of this field. The main purpose of these Symposia has been to address vital questions that impact our understanding of the causation, dependency, progression, resistance, and prevention of hormonally-associated cancers. We are indebted to the Scientific Advisory Board members who worked with us reviewing and offering suggestions to finalize the scientific program. We offer special thanks for the guidance and support of Dr. Gerald Mueller. His wisdom played an indispensable role in maintaining the excellence of these Symposia. We also acknowledge the numerous external reviewers that worked diligently to revise and improve the quality of the manuscripts. We are very grateful to Ms. Tandria Price.
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Keywords

  • biology
  • cancer
  • carcinogenesis
  • cell
  • endometrium
  • hormones
  • liver
  • metabolism
  • molecular biology
  • ovarian cancer
  • prevention
  • prostate cancer
  • resistance
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Editors and Affiliations

  • Division of Etiology and Prevention of Hormonal Cancers, The University of Kansas Medical Center, Kansas City

    Jonathan J. Li, Sara A. Li

  • Departmento de Patologia, Facultad de Medicina y Odontologia, Valencia, Spain

    Antonio Llombart-Bosch

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Bibliographic Information

  • Book Title: Hormonal Carcinogenesis IV

  • Editors: Jonathan J. Li, Sara A. Li, Antonio Llombart-Bosch

  • DOI: https://doi.org/10.1007/b102371

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag US 2005

  • Hardcover ISBN: 978-0-387-23783-1Published: 17 December 2004

  • eBook ISBN: 978-0-387-23761-9Published: 10 August 2006

  • Edition Number: 1

  • Number of Pages: XXVI, 546

  • Topics: Oncology, Cancer Research, Medical Microbiology, Cell Biology

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Access via your institution

Buy it now

eBook USD 129.00
Price excludes VAT (Canada)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 169.99
Price excludes VAT (Canada)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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