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Table of contents

About this book

Introduction

In this volume of Reviews there are three outstanding articles, one on phspholipase D, an enzyme that is widely distributed in bacteria, protozoa, fungi, plants and animals. Phospholipase D carries out a transphosphatidylation reaction, which is unique to this enzyme. This review is focussed on mammalian PLDs. The second review deals with endotoxin tolerance, the term which describes the phenomenon that immune responses and metabolic changes are mitigated after repeated LPS administration. The third article summarizes the current knowledge relevant to understanding the molecular basis of GPCR function and focusses on the underlying mechanisms of GPCR malfunctions responsible for diferent human diseases.

Keywords

Endotoxin G-protein-coupled receptors GPCR LPS PLD immune response phospholipase transmembrane receptors transphosphatidylation reaction bacteria biochemistry enzyme enzymes membrane receptor pharmacology physiology protein receptor research

Bibliographic information

  • DOI https://doi.org/10.1007/BFb0116584
  • Copyright Information Springer-Verlag 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-42814-5
  • Online ISBN 978-3-540-45534-9
  • Series Print ISSN 0303-4240
  • Series Online ISSN 1617-5786
  • Buy this book on publisher's site