Co-signal Molecules in T Cell Activation

Immune Regulation in Health and Disease

  • Miyuki Azuma
  • Hideo Yagita

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1189)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Basic Understanding of Co-signal Molecules in T Cell Activation

    1. Front Matter
      Pages 1-1
    2. Shigenori Nagai, Miyuki Azuma
      Pages 25-51
    3. Takanori So, Naoto Ishii
      Pages 53-84
    4. Michelle Schorer, Vijay K. Kuchroo, Nicole Joller
      Pages 153-177
    5. James Badger Wing, Christopher Tay, Shimon Sakaguchi
      Pages 179-210
  3. Co-signal Molecules in Health and Disease

    1. Front Matter
      Pages 211-211
    2. Taku Okazaki, Il-mi Okazaki
      Pages 213-232
    3. Pia Kivisäkk, Samia J. Khoury
      Pages 233-265
    4. Melissa Y. Yeung, Tanja Grimmig, Mohamed H. Sayegh
      Pages 267-312
    5. Masao Nakajima, Koji Tamada
      Pages 313-326

About this book


This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.  


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Editors and affiliations

  • Miyuki Azuma
    • 1
  • Hideo Yagita
    • 2
  1. 1.Department of Molecular Immunology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Department of ImmunologyJuntendo University School of MedicineTokyoJapan

Bibliographic information