Overview
- Highlights designing and fabrication of microfluidic chips and their biomedical applications
- Present strategies for designing organ-on-a-chip and human-on-a-chip
- Reviews microfluidic devices for drug delivery systems and drug screening
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About this book
This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation,ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
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Keywords
Table of contents (29 chapters)
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Front Matter
Editors and Affiliations
About the editor
Dr. PV. Mohanan is a Fellow of the National Academy of Science and Royal Society of Biologists, UK. He was a JSPS Post-Doctoral Fellow at the University of Tsukuba, Japan, in the field of Neurotoxicity. He joined Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Govt. of India, in 1989. As a toxicologist, he has been intimately associated with all the medical devices/technologies developed at SCTIMST. Currently, he heads the Division of Toxicology and a visiting professor and visiting researcher at Toyo University, Japan, and a Certified Biological Safety Specialist. He received a lifetime achievement award from the Society of Toxicology India for the outstanding contribution to toxicology research. Dr. Mohanan made significant contributions to the development of medical device regulations in India. He received a certificate of appreciation from the Hon. Minister of Science and Technology, Govt. of India, contributed to getting full adherent status on GLP from the OECD. He has authored more than 250 publications and edited 4 books. Presently, he is the Secretary-General of Society of Toxicology, India, and General Secretary of Indian JSPS Alumni Association.
Bibliographic Information
Book Title: Microfluidics and Multi Organs on Chip
Editors: P. V. Mohanan
DOI: https://doi.org/10.1007/978-981-19-1379-2
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022
Hardcover ISBN: 978-981-19-1378-5Published: 13 July 2022
Softcover ISBN: 978-981-19-1381-5Published: 14 July 2023
eBook ISBN: 978-981-19-1379-2Published: 11 July 2022
Edition Number: 1
Number of Pages: IX, 717
Number of Illustrations: 1 b/w illustrations
Topics: Biomedicine, general, Biomedical Engineering and Bioengineering, Cell Biology