© 2020

Health Impacts of Developmental Exposure to Environmental Chemicals

  • Reiko Kishi
  • Philippe Grandjean

Table of contents

  1. Front Matter
    Pages i-xi
  2. Introduction

  3. Adverse Health Effects on Human Developing Organs Caused by Environmental Chemicals-the Role That Chemicals Might Play

    1. Front Matter
      Pages 23-23
    2. Machiko Minatoya, Tomoyuki Hanaoka, Reiko Kishi
      Pages 25-53
    3. Tomoyuki Hanaoka, Chihiro Miyashita, Kumiko Itoh, Reiko Kishi
      Pages 55-68
    4. Takahiko Mitsui, Fumihiro Sata, Reiko Kishi
      Pages 69-99
    5. Atsuko Araki, Tina Kold Jensen
      Pages 101-129
    6. Sachiko Itoh
      Pages 131-152
    7. Carsten Heilmann, Philippe Grandjean
      Pages 175-190
  4. Impact of Environmental Chemical Hazards on Human Development

    1. Front Matter
      Pages 221-221
    2. Ching-Chung Lin, Meng-Shan Tsai, Mei-Huei Chen, Pau-Chung Chen
      Pages 247-277
    3. Kyungho Choi, Sunmi Kim
      Pages 359-373
    4. Hui-Ju Wen, Han-Bin Huang, Tsung-Lin Tsai, Shu-Li Wang
      Pages 375-404
    5. Mei-Lien Chen, Chia-Huang Chang, Machiko Minatoya
      Pages 405-437

About this book


This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to theimpacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children’s environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines further research directions and related policymaking aspects.

Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children’s health can be affected by harmful chemicals and other environmental toxicants.


Congenital Heart Malformation Birth Defect Low Birth Weight ADHD ASD Environmental Chemical Hazards PM 2.5 Hazardous Material DOHaD Environmental Toxicant

Editors and affiliations

  • Reiko Kishi
    • 1
  • Philippe Grandjean
    • 2
  1. 1.Center for Environmental and Health SciencesHokkaido UniversitySapporoJapan
  2. 2.Department of Environmental Health Harvard T.H. Chan School of Public HealthBostonUSA

About the editors

Reiko Kishi

Center for Environmental and Health Sciences

Hokkaido University


Hokkaido, Japan


Philippe Grandjean

Harvard T.H. Chan School of Public Health

Department of Environmental Health


Massachusetts, USA


University of Southern Denmark

Department of Environmental Medicine



Bibliographic information

  • Book Title Health Impacts of Developmental Exposure to Environmental Chemicals
  • Editors Reiko Kishi
    Philippe Grandjean
  • Series Title Current Topics in Environmental Health and Preventive Medicine
  • Series Abbreviated Title Current Topics in Environmental Health and Preventive Medicine
  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2020
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-981-15-0519-5
  • Softcover ISBN 978-981-15-0522-5
  • eBook ISBN 978-981-15-0520-1
  • Series ISSN 2364-8333
  • Series E-ISSN 2364-8341
  • Edition Number 1
  • Number of Pages XI, 557
  • Number of Illustrations 27 b/w illustrations, 23 illustrations in colour
  • Topics Health Promotion and Disease Prevention
    Maternal and Child Health
  • Buy this book on publisher's site


“I believe government agency officials will also find it useful. … This book provides a helpful review of major developmental issues for contemporary chemical entities such as the per fluorinated compounds and many others.” (John T. Pierce, Doody’s Book Reviews, August 21, 2020)