Small Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration

  • Sung-Tsang Hsieh
  • Praveen Anand
  • Christopher H. Gibbons
  • Claudia Sommer

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Overview and Assessments of Small Fiber Neuropathy

    1. Front Matter
      Pages 1-1
    2. Ming-Tsung Tseng, Chun-Liang Pan, Sung-Tsang Hsieh
      Pages 3-10
    3. Ahmad R. Abuzinadah, Christopher H. Gibbons
      Pages 43-55
  3. Small Fiber Neuropathy in Peripheral Nerve Disorders

    1. Front Matter
      Pages 57-57
    2. Christopher H. Gibbons
      Pages 59-72
    3. Rosario Privitera, Praveen Anand
      Pages 73-82
    4. Chi-Chao Chao, Hung-Wei Kan, Ti-Yen Yeh, Ya-Yin Cheng, Sung-Tsang Hsieh
      Pages 83-97
    5. Ahmad R. Abuzinadah, Christopher H. Gibbons
      Pages 109-118
  4. Roles of Small Fiber Pathology: Pain Syndromes and Neurodegeneration

    1. Front Matter
      Pages 119-119
    2. Claudia Sommer, Nurcan Üçeyler
      Pages 121-129
    3. Rosario Privitera, Praveen Anand
      Pages 131-139
    4. Kathrin Doppler, Claudia Sommer
      Pages 141-150
  5. Neuropathic Pain in Small Fiber Neuropathy: Mechanisms and Therapy

    1. Front Matter
      Pages 151-151
    2. Ming-Chang Chiang, Paul-Chen Hsieh, Sung-Tsang Hsieh
      Pages 153-164
    3. Ahmad R. Abuzinadah, Christopher H. Gibbons
      Pages 165-177
  6. Back Matter
    Pages 179-184

About this book


This book provides comprehensive coverage of small fiber neuropathy (SFN), from diagnosis to therapy. It focuses on nerve degeneration and neuropathic pain, and their underlying pathology, physiology, psychophysics, genetics and imaging. In particular, this book describes and discusses the major advances in diagnostic techniques for assessing SFN. These include skin biopsy, evoked potentials, quantitative sensory testing and functional studies, as biomarkers of SFN.

SFN is a common peripheral nerve disorder, but was often overlooked due to a lack of objective and specific diagnostic tests for the assessment of small nerve fibers. These fibers mediate thermal sensation, pain detection (nociception), and autonomic regulation. Major symptoms of SFN include neuropathic pain, impaired sensation and autonomic dysfunction. Neuropathic pain poses a diagnostic challenge to clinicians, an essential step for selecting appropriate treatment to relieve suffering.

SFN frequently develops in systemic diseases such as diabetes mellitus, following chemotherapy, infections etc., or presents as a major feature of various genetic neuropathies (e.g. channelopathy and familial amyloidosis). In addition to describing these conditions which lead to SFN, this book also describes related syndromes of neurodegeneration and pain, including fibromyalgia, visceral pain and hypersensitivity.

This definitive book covers both clinical aspects and research progress, which provides in-depth and up-to-date information on SFN. It would be immensely useful for clinicians, neurologists, neuroscientists, diabetologists, and pain specialists.

Dr. Sung-Tsang Hsieh is a professor at Department of Neurology and Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taiwan. He is also the associate dean of College of Medicine, National Taiwan University, Taiwan. Dr. Praveen Anand is a professor at Department of Clinical Neurology and head of Centre for Clinical Translation, Hammersmith Hospital, UK. Dr. Christopher Gibbons is an associate professor of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, USA. Dr. Claudia Sommer is a professor of Neurology at the Department of Neurology, Würzburg University Hospital, Germany.


Small fiber neuropathy peripheral neuropathy nociception pain autonomic nerve neurodegeneration diabetic neuropathy

Editors and affiliations

  • Sung-Tsang Hsieh
    • 1
  • Praveen Anand
    • 2
  • Christopher H. Gibbons
    • 3
  • Claudia Sommer
    • 4
  1. 1.Department of NeurologyNational Taiwan University HospitalTaipeiTaiwan
  2. 2.Department of NeurologyImperial College London, Hammersmith HospitalLondonUK
  3. 3.Department of NeurologyHarvard Medical School, Beth Israel Deaconess Medical CenterBostonUSA
  4. 4.Neurologische KlinikUniversitätsklinikum Würzburg WürzburgGermany

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-981-13-3545-7
  • Online ISBN 978-981-13-3546-4
  • Buy this book on publisher's site