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  • © 2018

HIV Vaccines and Cure

The Path Towards Finding an Effective Cure and Vaccine

  • Providing a comprehensive review of the major barriers to HIV cure and vaccine

  • Covering the fundamental virology and immunology of HIV

  • Discussing the challenges related to development of HIV vaccine and its clinical trials

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1075)

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eBook USD 139.00
Price excludes VAT (USA)
  • ISBN: 978-981-13-0484-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
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  • Tax calculation will be finalised during checkout
Softcover Book USD 179.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xv
  2. HIV Vaccines

    1. Front Matter

      Pages 1-1
    2. HIV Vaccine Efficacy Trials: RV144 and Beyond

      • Elizabeth Heger, Alexandra Schuetz, Sandhya Vasan
      Pages 3-30
    3. HIV T-Cell Vaccines

      • Beatriz Mothe, Christian Brander
      Pages 31-51
    4. Monkey Models and HIV Vaccine Research

      • Zhiwei Chen
      Pages 97-124
    5. Treatment of HIV for the Prevention of Transmission in Discordant Couples and at the Population Level

      • M. Kumi Smith, Britta L. Jewell, Timothy B. Hallett, Myron S. Cohen
      Pages 125-162
  3. HIV Cure

    1. Front Matter

      Pages 163-163
    2. HIV Persistence on Antiretroviral Therapy and Barriers to a Cure

      • Julia Marsh Sung, David M. Margolis
      Pages 165-185
    3. The Molecular Biology of HIV Latency

      • Georges Khoury, Gilles Darcis, Michelle Y. Lee, Sophie Bouchat, Benoit Van Driessche, Damian F. J. Purcell et al.
      Pages 187-212
    4. Cellular Determinants of HIV Persistence on Antiretroviral Therapy

      • Anastassia Mikhailova, Jose Carlos Valle-Casuso, Asier Sáez-Cirión
      Pages 213-239
    5. In Vitro and In Vivo Models of HIV Latency

      • James B. Whitney, R. Brad Jones
      Pages 241-263
    6. Measuring HIV Persistence on Antiretroviral Therapy

      • Bethany A. Horsburgh, Sarah Palmer
      Pages 265-284
    7. Clinical Interventions in HIV Cure Research

      • Thomas Aagaard Rasmussen, Ole S. Søgaard
      Pages 285-318

About this book

This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.

Keywords

  • HIV
  • Cure
  • Latency
  • Vaccine
  • Antibody
  • vaccines

Editors and Affiliations

  • Comprehensive AIDS Research Center, School of Medicine, Tsinghua University, Beijing, China

    Linqi Zhang

  • The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia

    Sharon R. Lewin

About the editors

Dr. Linqi Zhang is a professor of Department of Basic Medical Sciences, and the director of Comprehensive AIDS Research Center, Tsinghua University. He is also an adjunct professor of Peking Union Medical College, China. Prof. Zhang was the Chief Scientist for the National Key Basic Research Projects of China “HIV Biology and its Immune Responses”. His research focuses on pathogenesis of HIV-1 and vaccine development against HIV-1. He has published more than 100 research articles on international journals in this field.

Dr. Sharon Lewin is a professor of Medicine at the University of Melbourne and the inaugural director of the Peter Doherty Institute for Infection and Immunity, a joint venture of the University of Melbourne and Royal Melbourne Hospital. She is a consultant physician at the Alfred Hospital and a practitioner fellow funded by the National Health and Medical Research Council of Australia. Prof. Lewin’s research focuses on understanding how HIV persists on antiretroviral therapy, developing early clinical trials to achieve a cure for HIV and understanding how HIV interacts with other viruses such as hepatitis B virus. She has published more than 250 research articles in these fields.

Bibliographic Information

Buying options

eBook USD 139.00
Price excludes VAT (USA)
  • ISBN: 978-981-13-0484-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 179.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)