Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches

  • Daniel Yuan Qiang  Wong

Part of the Springer Theses book series (Springer Theses)

About this book


This thesis describes the authors’ pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these “secret allies” contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immune responses to malignancies, eliminating residual cancer cells.


Immuno-Modulation by Platinum-based Complexes Chemoselective Imine Ligation Platinum(IV) Prodrugs Cisplatin Prodrugs HER2-Targeted Platinum(IV) Anticancer Prodrugs Multimodal Anticancer Agents Chemotherapeutic Platinum Complexes Platinum(IV)-Peptide Conjugates Platinum(IV) Prodrug Scaffold Targeted Necrosis

Authors and affiliations

  • Daniel Yuan Qiang  Wong
    • 1
  1. 1.Department of ChemistryNational University of SingaporeSingaporeSingapore

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