Biosensors Based on Sandwich Assays

This book shows the various sandwich assays that are constructed from recognition molecules, such as antibodies, oligonucleotide sequences and aptamers, developed as a result of nano- and biotechnology advances. It consists of ten chapters presenting interesting examples of these assays, organized according to the type of analytic methods (colorimetric, fluorescence, electrochemical, etc.) and detected objects (protein, nucleic acid, small-molecule, ion, etc.). It also includes a chapter discussing the introduction of sandwich assays as biosensors for the detection of a range of targets. It is an interesting and useful resource for a wide readership in various fields of chemical science and nanotechnology.

• Analytic methods
• Biomolecule detection
• Clinic diagnostics
• Recognition molecules
• Sandwich assays
• Signaling markers
• Specificity and sensitivity
• Supersandwich assays

“This book is fairly comprehensive in its coverage and provides useful insights into a multitude of unique research endeavors beyond biosensors and sandwich assays. These insights include an extensive discussion devoted to the relevance of analytes at varying molecular levels, fundamentals, and developments in complementary and utilitarian detection techniques, as well as materials science considerations.” (Susana Campuzano, Analytical and Bioanalytical Chemistry, Vol. 410, 2018)

• Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China

  Fan Xia, Xiaojin Zhang, Xiaoding Lou

• College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China

  Quan Yuan

Fan Xia is currently a professor at Huazhong University of Science and Technology (HUST) and Dean of the Faculty of Materials Science and Chemistry, China University of Geosciences (Wuhan). He received his BSc degree (2003) from HUST and PhD degree (2008) from the Institute of Chemistry, Chinese Academy of Sciences (ICCAS) (Lei Jiang’s group). He then worked as a postdoctoral fellow in Prof. Alan J. Heeger’s group at the University of California, Santa Barbara. He joined HUST as part of the 1000 Young Talents Program in 2012. His scientific interest focuses on bio-analytical chemistry.

Xiaojin Zhang is currently a professor at China University of Geosciences (Wuhan). He received his BSc (2007) and PhD degrees (2012) from Wuhan University (Renxi Zhuo’s group). He then worked as a postdoctoral fellow in Prof. Peter X. Ma’s group at the University of Michigan, Ann Arbor. He joined China University of Geosciences (Wuhan) in 2016. His scientific interests focus on nanomaterials for theranostics.

Xiaoding Lou is currently a professor at China University of Geosciences (Wuhan). She received her PhD degree (2012) from Wuhan University (Zhen Li’s group). She then worked as a research associate in Prof. Ben Zhong Tang’s group at the Hong Kong University of Science and Technology. She joined China University of Geosciences (Wuhan) in 2017. Her scientific interests focus on the chemical and biosensor field.

Quan Yuan is currently a professor at Wuhan University. She received her BSc degree (2004) from Wuhan University and PhD degree (2009) from Peking University (Chunhua Yan’s group). She then worked as a postdoctoral fellow in Prof. Weihong Tan’s group at the University of Florida. She joined Wuhan University in 2011. Her scientific interests focus on upconversion nanoparticles and DNA nanotechnology.

Policies and ethics