Therapeutic Angiogenesis

  • Yukihito Higashi
  • Toyoaki Murohara

Table of contents

  1. Front Matter
    Pages i-vi
  2. Yukihito Higashi, Toyoaki Murohara
    Pages 1-2
  3. Cell Therapy

    1. Front Matter
      Pages 3-3
    2. Masayoshi Suda, Ippei Shimizu, Yohko Yoshida, Tohru Minamino
      Pages 25-43
    3. Takayuki Asahara, Haruchika Masuda
      Pages 45-66
    4. Hiroshi Kurazumi, Tohru Hosoyama, Kimikazu Hamano
      Pages 81-98
  4. Gene Therapy

    1. Front Matter
      Pages 109-109
    2. Brendan A. S. McIntyre, Takayuki Asahara, Cantas Alev
      Pages 111-131
    3. Jun Muratsu, Fumihiro Sanada, Yoshiaki Taniyama, Yuka Ikeda-Iwabu, Rei Otsu, Kana Shibata et al.
      Pages 133-144
    4. Michiko Tanaka, Yoshikazu Yonemitsu
      Pages 145-158
  5. Other Therapy

    1. Front Matter
      Pages 159-159
    2. Akimichi Iwamoto, Takayuki Hidaka, Yasuki Kihara, Hiroshi Kubo, Yukihito Higashi
      Pages 161-175
    3. Kenta Ito, Tomohiko Shindo, Hiroaki Shimokawa
      Pages 177-190
    4. Yasuyuki Fujita, Atsuhiko Kawamoto
      Pages 191-216
    5. Masaaki Miyata, Mitsuru Ohishi, Chuwa Tei
      Pages 217-227
    6. Tatsuya Maruhashi, Yasuki Kihara, Yukihito Higashi
      Pages 229-245
    7. Kaku Nakano, Jun-ichiro Koga, Kensuke Egashira
      Pages 247-266

About this book


The book discusses recent findings and current perspectives on therapeutic angiogenesis. Studies have shown that therapies such as cell implantation and transfer of gene encoding for angiogenic growth factors are effective in improving symptoms in patients with critical limb ischemia, who previously had no treatment option other than amputation. The book discusses these therapies and presents data collected in clinical studies over the past decade.

Despite significant advances in therapeutic angiogenesis since the first clinical studies in the early 21st century, it has been largely ignored in the literature. This comprehensive book fills that gap, making it a valuable resource for both researchers and practitioners alike.


Ischemic symptoms Limb ischemia Arterial disease Cell implantation Gene coding for angiogenic growth factors Irradiation of pulsed ultrasound Shock wave Tissue engineering Waon therapy

Editors and affiliations

  • Yukihito Higashi
    • 1
  • Toyoaki Murohara
    • 2
  1. 1.Research Institute for Radiation Biology and MedicineHiroshima UniversityHiroshimaJapan
  2. 2.Department of CardiologyNagoya UniversityAichiJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2017
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine
  • Print ISBN 978-981-10-2743-7
  • Online ISBN 978-981-10-2744-4
  • About this book