© 2017

Moyamoya Disease Explored Through RNF213

Genetics, Molecular Pathology, and Clinical Sciences

  • Akio Koizumi
  • Kazuhiro Nagata
  • Kiyohiro Houkin
  • Teiji Tominaga
  • Susumu Miyamoto
  • Shigeo Kure
  • Elizabeth Tournier-Lasserve

Table of contents

  1. Front Matter
    Pages i-viii
  2. Prologue

    1. Front Matter
      Pages 1-1
    2. Akio Koizumi, Shohab Youssefian
      Pages 3-12
    3. Haruto Uchino, Ken Kazumata, Kiyohiro Houkin
      Pages 13-22
  3. Genetic Epidemiology

    1. Front Matter
      Pages 23-23
  4. Biochemistry, Function and Molecular Pathology

    1. Front Matter
      Pages 43-43
    2. Daisuke Morito, Kazuhiro Nagata
      Pages 45-57
    3. Daisuke Morito, Kazuhiro Nagata
      Pages 59-67
    4. S. Guey, M. Kraemer, L. Grangeon, F. Riant, M. Kossorotoff, D. Hervé et al.
      Pages 103-118
  5. Clinical Management

    1. Front Matter
      Pages 119-119
    2. Yohei Mineharu, Yasushi Takagi, Susumu Miyamoto
      Pages 137-150
    3. Zheng-Shan Zhang, Lian Duan
      Pages 151-159
    4. Niklas von Spreckelsen, Boris Krischek
      Pages 161-168
    5. Satoru Miyawaki, Hideaki Imai, Nobuhito Saito
      Pages 169-176
  6. Epilogue

    1. Front Matter
      Pages 177-177

About this book


This book presents the latest findings on biological, epidemiological, and clinical investigations of RNF213, which is thought to be involved in many biological processes and plays a key role in cerebro- and cardiovascular disease . By discussing the epidemiology and genetic epidemiology of the disease with a particular focus on the molecular function of RNF213, research using animal models, diagnosis, therapy and clinical management around the world, this work makes a valuable contribution to the study of the disease.
Moyamoya Disease Explored Through RNF213 is an indispensable resource for both beginning and experienced researchers, pediatricians, neurologists, and neurosurgeons who are seeking comprehensive information on adult and childhood stroke.


MMD RNF213 Molecular Epidemicology MRI CT Stroke Blood Clot

Editors and affiliations

  • Akio Koizumi
    • 1
  • Kazuhiro Nagata
    • 2
  • Kiyohiro Houkin
    • 3
  • Teiji Tominaga
    • 4
  • Susumu Miyamoto
    • 5
  • Shigeo Kure
    • 6
  • Elizabeth Tournier-Lasserve
    • 7
  1. 1.Department of Health and Environmental SciencesKyoto University Graduate School of MedicineKyotoJapan
  2. 2.Faculty of Life SciencesKyoto Sangyo UniversityKyotoJapan
  3. 3.Department of NeurosurgeryHokkaido University Graduate School of MedicineSapporoJapan
  4. 4.Department of NeurosurgeryTohoku University School of MedicineSendaiJapan
  5. 5.Department of NeurosurgeryKyoto University Graduate School of MedicineKyotoJapan
  6. 6.Department of PediatricsTohoku University School of MedicineSendaiJapan
  7. 7.CHU Paris‐GH St‐Louis Lariboisière F‐WidalHôpital LariboisièreParisFrance

About the editors

Akio Koizumi, Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University

Kazuhiro Nagata, Laboratory of Molecular and Cellular biology, Faculty of Life Sciences, Kyoto Sangyo University

Kiyohiro Houkin, Department of Neurosurgery, Graduate School of Medicine, Hokkaido University

Teiji Tominaga, Department of Neurosurgery, Tohoku University School of Medicine 

Susumu Miyamoto, Department of Neurosurgery, Graduate School of Medicine, Kyoto University

Shigeo Kure, Department of Pediatrics, Tohoku University School of Medicine

Elizabeth Tournier‐Lasserve, CHU Paris‐GH St‐Louis Lariboisière F‐Widal ‐ Hôpital Lariboisière

Bibliographic information

  • Book Title Moyamoya Disease Explored Through RNF213
  • Book Subtitle Genetics, Molecular Pathology, and Clinical Sciences
  • Editors Akio Koizumi
    Kazuhiro Nagata
    Kiyohiro Houkin
    Teiji Tominaga
    Susumu Miyamoto
    Shigeo Kure
    Elizabeth Tournier-Lasserve
  • Series Title Current Topics in Environmental Health and Preventive Medicine
  • Series Abbreviated Title Current Topics in Environmental Health and Preventive Medicine
  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2017
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-981-10-2710-9
  • Softcover ISBN 978-981-10-9689-1
  • eBook ISBN 978-981-10-2711-6
  • Series ISSN 2364-8333
  • Series E-ISSN 2364-8341
  • Edition Number 1
  • Number of Pages VIII, 185
  • Number of Illustrations 14 b/w illustrations, 22 illustrations in colour
  • Topics Neurology
    Public Health
  • Buy this book on publisher's site