• Jong Hoon Park
  • Curie Ahn

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 933)

Table of contents

  1. Front Matter
    Pages i-ix
  2. ADPKD Overview

    1. Front Matter
      Pages 1-1
    2. Yu Bin Shin, Jong Hoon Park
      Pages 3-11
    3. Do Yeon Kim, Jong Hoon Park
      Pages 13-22
  3. Cystogenesis Mechanisms

    1. Front Matter
      Pages 23-23
    2. Hyowon Mun, Jong Hoon Park
      Pages 35-44
  4. Therapeutic Approaches and Diagnostic Markers for ADPKD

    1. Front Matter
      Pages 69-69
    2. Yu Mi Woo, Je Yeong Ko, Eun Ji Lee
      Pages 71-84
    3. Hayne Cho Park, Curie Ahn
      Pages 85-103
    4. Hyunsuk Kim, Young-Hwan Hwang
      Pages 105-121
  5. Back Matter
    Pages 123-126

About this book


This book covers the mechanisms of renal cyst development as well as the aberrant signaling pathways which are involved in Autosomal Dominant Polycystic Kidney Disease (ADPKD). ADPKD is a genetic disease in which cysts appear in the epithelial lining of both kidneys. End stage ADPKD patients experience renal failure and require dialysis or a renal transplantation. There are no specific targeted therapies for ADPKD currently available, making it important to understand the basic cellular mechanisms underlying the onset and progression of ADPKD, in order to identify potential therapeutic targets for the disease.

Several therapeutic approaches that have been attempted to date are reviewed. This work provides a broad overview of ADPKD and highlights the key challenges currently faced by researchers in this field. Furthermore, it provides insight into ADPKD to facilitate the development of novel biomarkers for ADPKD and to direct future research into this challenging pathology.

This book is suitable for clinicians who have encountered patients with ADPKD, for clinicians / researchers working in the field of ADPKD and more generally on the kidney and kidney related disorders and for students of medicine with an interest in internal medicine.


Autosomal Dominant Polycystic Kidney Disease (ADPKD) Cyst End-stage Renal Disease (ESRD) Genetic mechanism Polycystic Kidney Disease (PKD) Polycystin (PC) Proliferation

Editors and affiliations

  • Jong Hoon Park
    • 1
  • Curie Ahn
    • 2
  1. 1.Department of Life systemsSookmyung Women’s UniversitySeoulKorea (Republic of)
  2. 2.Department of Internal MedicineSeoul National University College of MedicineSeoulKorea (Republic of)

Bibliographic information