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Mutant p53 and MDM2 in Cancer

  • Book
  • © 2014


  • Articles contributed by leading scientists in the field
  • Discusses detailed molecular events leading to oncogenesis
  • Useful for scientists of all levels
  • Includes supplementary material:

Part of the book series: Subcellular Biochemistry (SCBI, volume 85)

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About this book

This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis.

This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.

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Table of contents (19 chapters)

Editors and Affiliations

  • Department of Biochemistry and Molecular Biology, and the Massey Cancer Center, Virginia Commonwealth University, Richmond, USA

    Swati Palit Deb, Sumitra Deb

Bibliographic Information

  • Book Title: Mutant p53 and MDM2 in Cancer

  • Editors: Swati Palit Deb, Sumitra Deb

  • Series Title: Subcellular Biochemistry

  • DOI:

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2014

  • Hardcover ISBN: 978-94-017-9210-3Published: 22 September 2014

  • Softcover ISBN: 978-94-024-0357-2Published: 10 September 2016

  • eBook ISBN: 978-94-017-9211-0Published: 08 September 2014

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: VIII, 373

  • Number of Illustrations: 2 b/w illustrations, 36 illustrations in colour

  • Topics: Cancer Research, Cell Biology, Oncology

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