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Mutant p53 and MDM2 in Cancer

  • Book
  • © 2014

Overview

Editors:
  1. Swati Palit Deb

    1. Department of Biochemistry and Molecular Biology, and the Massey Cancer Center, Virginia Commonwealth University, Richmond, USA

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  2. Sumitra Deb

    1. Department of Biochemistry and Molecular Biology, and the Massey Cancer Center, Virginia Commonwealth University, Richmond, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Articles contributed by leading scientists in the field
  • Discusses detailed molecular events leading to oncogenesis
  • Useful for scientists of all levels
  • Includes supplementary material: sn.pub/extras

Part of the book series: Subcellular Biochemistry (SCBI, volume 85)

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About this book

This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis.

This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. p53 and Hereditary Cancer

    • Diana Merino, David Malkin
    Pages 1-16

  3. Alterations of p63 and p73 in Human Cancers

    • Kazushi Inoue, Elizabeth A. Fry
    Pages 17-40

  4. Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer

    • Javier E. Girardini, Dawid Walerych, Giannino Del Sal
    Pages 41-70

  5. p53: Its Mutations and Their Impact on Transcription

    • Catherine Vaughan, Isabella Pearsall, Andrew Yeudall, Swati Palit Deb, Sumitra Deb
    Pages 71-90

  6. Transcriptional Regulation by Mutant p53 and Oncogenesis

    • Raffaela Santoro, Sabrina Strano, Giovanni Blandino
    Pages 91-103

  7. p53 Mutation in the Genesis of Metastasis

    • W. A. Yeudall
    Pages 105-117

  8. Structural Studies on Mechanisms to Activate Mutant p53

    • Hector Viadiu, Gilberto Fronza, Alberto Inga
    Pages 119-132

  9. Mutant p53 and the Response to Chemotherapy and Radiation

    • Leila Tchelebi, Hani Ashamalla, Paul R. Graves
    Pages 133-159

  10. The p53-Mdm2 Loop: A Critical Juncture of Stress Response

    • Yaara Levav-Cohen, Zehavit Goldberg, Kah Hin Tan, Osnat Alsheich-Bartok, Valentina Zuckerman, Sue Haupt et al.
    Pages 161-186

  11. Mechanisms of Mutant p53 Stabilization in Cancer

    • Rebecca A. Frum, Steven R. Grossman
    Pages 187-197

  12. Crosstalk Between Mdm2, p53 and HIF1-α: Distinct Responses to Oxygen Stress and Implications for Tumour Hypoxia

    • E. Douglas Robertson, Kostyantyn Semenchenko, Bohdan Wasylyk
    Pages 199-214

  13. MDM2 Overexpression, Activation of Signaling Networks, and Cell Proliferation

    • Swati Palit Deb, Shilpa Singh, Sumitra Deb
    Pages 215-234

  14. p53-Independent Effects of Mdm2

    • Stephen Bohlman, James J. Manfredi
    Pages 235-246

  15. Splice Variants of MDM2 in Oncogenesis

    • Melissa Rosso, Danielle E. Okoro, Jill Bargonetti
    Pages 247-261

  16. Mdm2 and MdmX Involvement in Human Cancer

    • Steven J. Berberich
    Pages 263-280

  17. Targeting p53-MDM2-MDMX Loop for Cancer Therapy

    • Qi Zhang, Shelya X. Zeng, Hua Lu
    Pages 281-319

  18. Involvement of p53 in the Repair of DNA Double Strand Breaks: Multifaceted Roles of p53 in Homologous Recombination Repair (HRR) and Non-Homologous End Joining (NHEJ)

    • Vijay Menon, Lawrence Povirk
    Pages 321-336

  19. The Role of Tumor Suppressor p53 in the Antioxidant Defense and Metabolism

    • Andrei V. Budanov
    Pages 337-358

  20. Lung Cancer Stem Cells, p53 Mutations and MDM2

    • Venkat Sundar Gadepalli, Swati Palit Deb, Sumitra Deb, Raj R. Rao
    Pages 359-370
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Editors and Affiliations

  • Department of Biochemistry and Molecular Biology, and the Massey Cancer Center, Virginia Commonwealth University, Richmond, USA

    Swati Palit Deb, Sumitra Deb

Bibliographic Information

  • Book Title: Mutant p53 and MDM2 in Cancer

  • Editors: Swati Palit Deb, Sumitra Deb

  • Series Title: Subcellular Biochemistry

  • DOI: https://doi.org/10.1007/978-94-017-9211-0

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2014

  • Hardcover ISBN: 978-94-017-9210-3Published: 22 September 2014

  • Softcover ISBN: 978-94-024-0357-2Published: 10 September 2016

  • eBook ISBN: 978-94-017-9211-0Published: 08 September 2014

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: VIII, 373

  • Number of Illustrations: 2 b/w illustrations, 36 illustrations in colour

  • Topics: Cancer Research, Cell Biology, Oncology

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