The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level

  • Mary Ann Asson-Batres
  • Cécile Rochette-Egly

Part of the Subcellular Biochemistry book series (SCBI, volume 70)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Doris M. Benbrook, Pierre Chambon, Cécile Rochette-Egly, Mary Ann Asson-Batres
    Pages 1-20
  3. Natacha Rochel, Dino Moras
    Pages 21-36
  4. Juliana Gutierrez-Mazariegos, Michael Schubert, Vincent Laudet
    Pages 55-73
  5. Federica Gilardi, Béatrice Desvergne
    Pages 75-102
  6. Aleksandr Piskunov, Ziad Al Tanoury, Cécile Rochette-Egly
    Pages 103-127
  7. Alison Urvalek, Kristian Bruun Laursen, Lorraine J. Gudas
    Pages 129-149
  8. Clara Nervi, Francesco Grignani
    Pages 151-179
  9. Marco-Antonio Mendoza-Parra, Hinrich Gronemeyer
    Pages 181-202
  10. Zhijie Liu, Qidong Hu, Michael G. Rosenfeld
    Pages 203-225
  11. Back Matter
    Pages 227-230

About this book

Introduction

A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases.

VOLUME I:

Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.

Keywords

RAR RXR Retinoic Acid Retinoids Vitamin A

Editors and affiliations

  • Mary Ann Asson-Batres
    • 1
  • Cécile Rochette-Egly
    • 2
  1. 1.Department of Biological SciencesTennessee State UniversityNashvilleUSA
  2. 2.IGBMCIllkirch CedexFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-017-9050-5
  • Copyright Information Springer Science+Business Media Dordrecht 2014
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-017-9049-9
  • Online ISBN 978-94-017-9050-5
  • Series Print ISSN 0306-0225
  • About this book