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The Benzodiazepines

Use, overuse, misuse, abuse

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  • © 1978


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About this book

The story of the benzodiazepines is a fascinating one: the synthesis of a long series of inert compounds and the abandonment of the project: months later, the renewal of the project and the discovery that this compound R05-0690 (Librium ®) was a sedative and muscle relaxant in laboratory animals: the recognition that its postulated structure was wrong and that it was in fact a member of an entirely new chemical class: the excitement caused by the discovery of the powerful taming effect of the drug in wild animals: the even greater excitement in medical circles when its dramatic anxiety relieving effects were cstablished in humans: the subsequent enormous world­ wide usc of drugs of the benzodiazepine group. I have reason to know the story well for during that period I worked in various capacities in research, marketing and manage­ ment in the British subsidiary of F. Hoffmann-Ia Roche. It was during this period that I became interested in whether dependence on benzodiazepines could occur and if so to what extent, but felt that this could be examined best from outside the concern. Having now retired from Roche back to academic medicine I have taken the opportunity to examine and analyse the evidence.

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Table of contents (16 chapters)

  1. Summary

  2. Glossary

  3. The general problem of dependence

  4. Benzodiazepine Dependence

  5. Significance of Benzodiazepine Dependence within the Community

  6. Conclusions

Authors and Affiliations

  • Medical Studies, Girton College, Cambridge, UK

    John Marks

Bibliographic Information

  • Book Title: The Benzodiazepines

  • Book Subtitle: Use, overuse, misuse, abuse

  • Authors: John Marks

  • DOI:

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: John Marks 1978

  • Softcover ISBN: 978-94-011-6205-0Published: 23 February 2012

  • eBook ISBN: 978-94-011-6203-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: IX, 111

  • Topics: Neurology, Pharmacology/Toxicology

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