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The Role of Pharmacology in Pediatric Oncology

  • Book
  • © 1987

Overview

Editors:
  1. D. G. Poplack

    1. Leukemia Biology Section, Pediatric Branch, National Institutes of Health, Bethesda, USA

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  2. L. Massimo

    1. Istituto Giannina Gaslini, Genova, Italy

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    You can also search for this editor in PubMed   Google Scholar

  3. P. Cornaglia-Ferraris

    1. Istituto Giannina Gaslini, Genova, Italy

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Oncology (DION, volume 44)

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Table of contents (25 chapters)

  1. Front Matter

    Pages I-XII
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  2. Principles of antineoplastic therapy in children

    1. Front Matter

      Pages 1-1
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    2. Clinical Pharmacokinetics for the Pediatric Oncologist

      • Jerry M. Collins
      Pages 3-13

    3. The pharmacology of antineoplastic agents in children

      • Frank M. Balis
      Pages 15-27

    4. Clinical pharmacology of anticancer drugs in children: differences and similarities between children and adults

      • William E. Evans, Clinton F. Stewart, Michael L. Christensen, William R. Crom
      Pages 29-71

  3. Pharmacologic reasons for treatment failure

    1. Front Matter

      Pages 73-73
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    2. Drug resistance in medical and pediatric oncology

      • Kenneth H. Cowan
      Pages 75-87

    3. Genetic reasons for pharmacologic treatment failure: gene amplification

      • Giuseppe Torelli
      Pages 89-95

    4. New approaches to overcome drug resistance

      • Vassilios Avramis, Robert Biener, John Holcenberg
      Pages 97-112

  4. Methods of drug delivery

    1. Front Matter

      Pages 113-113
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    2. New methods of administering old drugs: IV infusion of mercaptopurine

      • Solomon Zimm, David G. Poplack
      Pages 115-123

    3. Regional therapy: an overview

      • Jerry M. Collins
      Pages 125-135

    4. Pharmacologic approaches to the treatment of central nervous system malignancy

      • David G. Poplack, Riccardo Riccardi
      Pages 137-156

  5. Use of new agents in children

    1. Front Matter

      Pages 157-157
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    2. Phase I and II trials in pediatric cancer patients: a rationale

      • Richard S. Ungerleider, Silvia Marsoni
      Pages 159-170

    3. Guidelines for conduct of Phase I studies in children

      • J. Holcenberg
      Pages 171-176

  6. Pharmacology of antileukemic agents

    1. Front Matter

      Pages 177-177
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    2. Factors affecting the clinical pharmacology of antileukemic drugs

      • Riccardo Riccardi, Anna Lasorella, Renato Mastrangelo
      Pages 179-184

    3. Potentiation of 6-mercaptopurine after time and dose-dependent pretreatment with methotrexate in malignant human T- and B-lymphoblasts

      • Jos P. M. Bökkerink, Ronney A. De Abreu, Marinka A. H. Bakker, Tilly W. Hulscher
      Pages 185-191

    4. The effect of methotrexate on purine and pyrimidine deoxyribonucleoside triphosphate pools and on cell viability and cell-phase distribution in malignant human T- and B-lymphoblasts

      • Ronney A. De Abreu, Jos P. M. Bökkerink, Marinka A. H. Bakker, Tilly W. Hulscher, John M. Van Baal
      Pages 193-200
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Keywords

About this book

The dramatic improvement made in recent years in the treatment of child­ hood malignancies has been in large part the result of advances in the field of pharmacology. Chemotherapy is the major therapeutic modality used to treat childhood cancer. Rational administration of antineoplastic chemo­ therapy to the child with cancer requires the pediatric oncologist to have a thorough understanding of the fundamental principles of clinical pharmaco­ logy, an intimate knowledge of the specific agents being used, and an aware­ ness of the unique biologic and physiologic features of children. In mid 1985, a distinguished group of pediatric oncologists and clinical pharmacologists convened in a unique workshop to review the subject of pharmacology in pediatric oncology. A goal of this workshop was to pro­ duce a book which would review this topic and present it in a format useful for the clinician. In this book basic principles of pharmacology, mechanisms of drug resis­ tance, new methods of drug delivery, guidelines for studying new agents in children, new biological response modifiers and the pharmacology of the most commonly used chemotherapeutic agents in children are reviewed in depth. Particular emphasis is given to discussing those topics which unique­ ly apply to the use of antineoplastic agents in children with cancer. The Editors VII Contents Preface . v Contents Vll List of Major Contributors Xl Principles of Antineoplastic Therapy in Children 1. Clinical pharmacokinetics for the pediatric oncologist ................ .

Editors and Affiliations

  • Leukemia Biology Section, Pediatric Branch, National Institutes of Health, Bethesda, USA

    D. G. Poplack

  • Istituto Giannina Gaslini, Genova, Italy

    L. Massimo, P. Cornaglia-Ferraris

Bibliographic Information

  • Book Title: The Role of Pharmacology in Pediatric Oncology

  • Editors: D. G. Poplack, L. Massimo, P. Cornaglia-Ferraris

  • Series Title: Developments in Oncology

  • DOI: https://doi.org/10.1007/978-94-009-4267-7

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishers, Dordrecht 1987

  • Softcover ISBN: 978-94-010-8395-9Published: 02 October 2011

  • eBook ISBN: 978-94-009-4267-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 336

  • Topics: Oncology

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